Esters of hyaluronic acid
First Claim
1. Total and partial esters of hyaluronic acid with alcohols of the aliphatic, araliphatic, cycloaliphatic and heterocyclic series and salts of such partial esters with inorganic or organic bases, with the exception of the total methyl ester of hyaluronic acid.
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Abstract
The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterfied, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases.
The compounds possess interesting and precious bioplastic and pharmaceutical properties and may be used in innumerable fields, including cosmetics, surgery and medicine. The invention also includes pharmaceutical preparations containing, as an active ingredient, one or more hyaluronic acid esters, or a salt thereof as described above, as well as medicaments containing:
(1) a pharmacologically active substance or an association of pharmacologically active substances and
(2) a carrying vehicle containing a total or partial ester of hyaluronic acid. The invention includes also various uses of the hyaluronic esters or of the above mentioned medicaments, such as in medicine, surgery or cosmetics.
The invention also relates to a new procedure for the preparation of polysaccharide esters containing carboxylic groups, such as in particular the above mentioned hyaluronic acid esters.
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Citations
48 Claims
- 1. Total and partial esters of hyaluronic acid with alcohols of the aliphatic, araliphatic, cycloaliphatic and heterocyclic series and salts of such partial esters with inorganic or organic bases, with the exception of the total methyl ester of hyaluronic acid.
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15. A medicament comprising:
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(a) one or more pharmacologically active substances and (b) a carrying vehicle comprising a total or partial ester of hyaluronic acid wth alcohols of the aliphatic, araliphatic, cycloaliphatic and heterocyclic series or salts of these partial esters with inorganic or organic bases. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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- 32. A process for the preparation of acidic polysaccharide esters containing carboxy groups, in which a quaternary ammonium salt of the polysaccharide is treated with an esterifying agent in an aprotic solvent, and, as desired, free carboxy groups are salified in the partial esters obtained, or salified groups are released in them.
- 40. The tetraalkylammonium salts of an acidic polysaccharide containing carboxy groups deriving from alkyls with between 1 and 6 carbon atoms.
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48. Acidic polysaccharide esters containing carboxy groups deriving from alkyls with between one and six carbon atoms, with the exception of the total methyl ester of hyaluronic acid.
Specification