Automatic radioisotope filling apparatus

• US 4,853,546 A
• Filed: 09/16/1987
• Issued: 08/01/1989
• Est. Priority Date: 09/16/1986
• Status: Expired due to Fees

• Current Assignee: UBE Industries Limited
• Original Assignee: UBE Industries Limited
• Inventors: Tanaka, Masaaki, Matsuno, Masao, Nagamatsu, Sunao, Abe, Shuzo, Matsunami, Satoshi
• Primary Examiner(s): Hannaher, Constantine
• Application Number:
  US07/097,025
• Time in Patent Office: 685 Days
• Field of Search: 250/432 PD, 422/62
• US Class Current: 250/432.0PD
• CPC Class Codes: G01N 1/38 Diluting, dispersing or mixing samples
• CPC Class Codes: G01T 7/02 Collecting means for receiving or storing samples to be investigated and possibly directly transporting the samples to the measuring arrangement; particularly for investigating radioactive fluids sampling, preparing specimens for investigation in general G01N1/00, G01N1/02; shielded cells or rooms structurally combined with manipulatin devices G21F; measuring of chromatographically separated samples G01N30/00 - G01N30/96
• CPC Class Codes: G21G 4/02 Neutron sources

Abstract

An automatic radioisotope filling apparatus which includes a radioisotope vial containing a radioisotope solution, a saline vial containing a physiological saline solution and a plurality of label vials containing a drug into which a predetermined amount of the radioisotope solution or the physiological saline solution is to be filled automatically. A required amount of the radioisotope solution or the physiological saline solution is automatically metered and automatically filled into each label vial and consequently the radiation exposure of the operator of the apparatus is minimized.

Claims

1. An automatic radioisotope filling apparatus which comprises:

a radioisotope vial containing a radioisotope solution,

a saline vial containing a physiological saline solution,

a plurality of label vials containing a drug into which a predetermined amount of the radioisotope solution or the physiological saline solution is to be provided from the radioisotope vial and the saline vial,

a container for said plurality of label vials,

conduit means for selectively transferring the radioisotope solution and the physiological saline solution from the radioisotope vial and the saline vial to each of the pluraltiy of label vials, and

means for selectively and automatically controlling the flow of said radioisotope solution and the physiological saline solution through said conduit means,

whereby a required amount of the radioisotope solution and the physiological saline solution for each of the label vials may be automatically withdrawn from the radioisotope vial and the saline vial and provided to each of the label vials.

2. An automatic radioisotope filling apparatus according to claim 1 wherein said container for said plurality of label vials is provided with a stirring mechanism.

3. An automatic radioisotope filling apparatus according to claim 1, wherein said conduit means includes a distributor for receiving said radioisotope solution and said physiological saline solution and directing the flow of said radioisotope solution and said physiological saline solution to each of said plurality of label vials.

4. An automatic radioisotope filling apparatus which comprises:

a radioisotope vial containing a radioisotope solution,

a saline vial containing a physiological saline solution,

a plurality of label vials containing a drug into which a predetermined amount of the radioisotope solution or the physiological saline solution is to be provided from the radioisotope vial and the saline vial,

a dilution vial,

conduit means including said dilution vial for selectively transferring the radioisotope solution and the physiological saline solution from the radioisotope vial and the saline vial to each of the plurality of label vials,

means for selectively and automatically controlling the flow of said radioisotope solution and the physiological saline solution through said conduit means including,

metering means for withdrawing and transferring a measured volume of the radioisotope solution from said radioisotope vial to said dilution vial,

a radiation detector for measuring the radioactive intensity of the radioisotope solution transferred to the dilution vial, and means for calculating the specific radioactivity of the radioisotope solution transferred to the dilution vial based on the measured volume and radioactive intensity of the radioisotope solution transferred to the dilution vial.

6. An automatic radioisotope filling apparatus according to claim 4 or 5, wherein said conduit means includes a plurality of tubes and further comprising a detector for fluid discontinuity provided in the middle of a tube connecting the radioisotope vial and the metering means.

7. An automatic radioisotope filling apparatus according to claim 4 or 5, wherein said conduit means includes a plurality of tubes and further comprising a pressure detector provided in the middle of a tube connecting the metering means and the dilution vial.

8. An automatic radioisotope filling apparatus according to claim 4 or 5, wherein said conduit means includes a plurality of tubes for transferring the radioisotope solution and the physiological solution and for venting gases during transfer of said solutions and said plurality of tubes are fixed for support on a sheet which provides an integral flow unit.

9. An automatic radioisotope filling apparatus according to claim 4 or 5, wherein the label vials are accomodated in a plurality of radiation-shielding lead containers fixed to a portable cartridge.

10. An automatic radioisotope filling apparatus according to claim 4 or 5, wherein a needle is inserted into each label vial for supplying or discharging a gas into or from the label vial, a tube is connected to the needle at one end, and the other end of the tube is connected to a buffer container.

11. An automatic radioisotope filling apparatus according to claim 4 or 5, wherein the label vials are provided with a stirring mechanism.

5. An apparatus for automatically providing a plurality of label vials containing a radioactive solution of a specific radioactivity comprising:

a radioisotope vial containing a radioisotope solution,

a saline vial containing a physiological saline solution,

a plurality of label vials containing a drug into which said radioisotope solution is to be provided,

a dilution vial,

conduit means for selectively transferring the radioisotope solution and the physiological saline solution from the radioisotope vial and the saline vial to the dilution vial,

metering means for withdrawing and transferring a measured volume of the radioisotope solution from said radioisotope vial to said dilution vial,

a radiation detector for measuring the radioactive intensity of the radioisotope solution transferred to the dilution vial, and

means for calculating the specific radioactivity of the radioisotope solution transferred to the dilution vial based on the measured volume and radioactive intensity of the radioisotope solution transferred to the dilution vial and determining a volume of the physiological saline solution required to adjust the radioactive intensity of the radioisotope solution in the dilution vial to a specific radioactivity,

metering means responsive to said calculating means for withdrawing and transferring said required volume of the physiological saline solution to said dilution vial, and

means for selectively transferring the radioisotope solution and physiological saline solution from said dilution vial to said label vials.