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1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds

  • US 4,855,316 A
  • Filed: 02/18/1988
  • Issued: 08/08/1989
  • Est. Priority Date: 02/18/1988
  • Status: Expired due to Term
First Claim
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1. A compound having structural Formula I ##STR10## wherein the methoxy groups attached to the cyclohexane moiety are cis to one another and the two nitrogen atoms attached to the cyclohexane moiety are trans to one another;

  • X is a direct bond, or is --O-- or --S--;

    R1 and R2, together with the nitrogen atom to which they are attached form a pyrrolidinyl ringA is selected from ##STR11## phenyl;

    phenyl substituted with from one to four halogen atoms;

    phenyl substituted with one or two alkyl groups of from one to four carbon atoms;

    phenyl substituted with one or two alkoxy groups of from one to four carbon atoms;

    orphenyl substituted with one or two alkyl groups of from one to four carbon atoms and one or two halogen atoms;

    ora pharmaceutically acceptable acid addition salt thereof.

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