Nucleoside analogues having antiviral activity

• US 4,859,677 A
• Filed: 04/17/1987
• Issued: 08/22/1989
• Est. Priority Date: 04/17/1987
• Status: Expired due to Fees

• Current Assignee: University of Kansas
• Original Assignee: University of Kansas
• Inventors: Borcherding, David R., Borchardt, Ronald T.
• Primary Examiner(s): Sutto, Anton H.
• Assistant Examiner(s): RIVERS, DIANA
• Application Number:
  US07/039,511
• Time in Patent Office: 858 Days
• Field of Search: 544/277, 514/261, 514/303, 546/118
• US Class Current: 514/263.4
• CPC Class Codes: C07D 471/04 Ortho-condensed systems
• CPC Class Codes: C07D 473/00 Heterocyclic compounds containing purine ring systems

Abstract

Compounds of the formula (I) ##STR1## wherein X is ═N-- or ═CH-- and physiologically acceptable salts and solvents thereof which have antiviral activity, a process for the preparation of the compounds and intermediates thereof, pharmaceutical compositions containing the compounds and a method for inhibiting the propagation of virus using the compounds.

Claims

1. A compound of the formula (I)

wherein X is ═

N-- or ═

CH-- or a physiologically acceptable salt or solvate thereof.

5. An antiviral composition comprising an effective antiviral amount of the compound of claim 1, and a pharmaceutically effective carrier.

16. A pharamaceutical composition comprising 0.1 to 99% by weight of the compound of claim 1 and a pharmaceutically effective carrier.

2. The compound of claim I which has the formula ##STR32##

3. The compound of claim 2, wherein X is ═

N--.

4. The compound of claim 2, wherein X is ═

CH--.

6. An antiviral composition comprising an effective antiviral amount of the compound of claim 2, and a pharmaceutically effective carrier.

7. The composition of claim 6, wherein X is ═

N--.

8. The composition of claim 6, wherein X is ═

CH--.

9. The composition of claim 7 which contains an effective anti poxvirus amount of said compound.

10. The composition of claim 8 which contains an effective anti poxvirus amount of said compound.

11. The composition of claim 7 which contains an effective anti reovirus amount of said compound.

12. The composition of claim 8 which contains an effective anti reovirus amount of said compound.

13. The composition of claim 7 which contains an effective anti measles, parainfluenza or vesicular stomatitis virus amount of said compound.

14. The composition of claim 8 which contains an effective anti measles, parainfluenza or vesicular stomatitis virus amount of said compound.

15. A method for treating viral infections which comprises administering an effective antiviral amount of the composition of claim 7 to a subject infected with poxvirus, reovirus, measles virus, parainfluenza virus or vesicular stomatitis virus.