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Calcium phosphate bone substitute materials

  • US 4,861,733 A
  • Filed: 02/13/1987
  • Issued: 08/29/1989
  • Est. Priority Date: 02/13/1987
  • Status: Expired due to Term
First Claim
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1. A uniform calcium phosphate-containing material useful as bone substitute material or for the manufacture of prosthetic devices, having a cancellous structure characteristic of boney tissue or bone or a substantially uniformly permeable microporous structure characterized by a substantially uniform pore volume in the range from about 10 to about 90% and by a pronounced three-dimensional fenestrate structure corresponding to the microstructure of the porous carbonate echinoderm or scleractinian coral skeletal material of marine life and providing a periodic minimal surface, said periodic minimal surface dividing the volume of said material into two interpenetrating regions, each of which is a single multiple connected domain, said material having a substantially uniform pore size diameter and substantially uniform pore connections or openings in the range from about 5 microns to about 500 microns, said material comprising a calcium phosphate having a calcium to phosphorus Ca/P atomic ratio in the range 1.0-2.0 and consisting essentially of a mixture of dicalcium phosphate Ca2 P2 O7 and tricalcium phosphate Ca3 P2 O8 or a mixture of tricalcium phosphate Ca3 P2 O8 and hydroxyapatite or a mixture of tetracalcium phosphate Ca4 P2 O9 and hydroxyapatite.

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