1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents
First Claim
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1. A compound of the formula ##STR8## wherein, A1 is hydrogen or methyl;
- and B and C together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine, morpholine or imidazole ring;
W is hydrogen, (C1 -C2)alkyl, (C1 -C2)alkoxy, chloro, or fluoro; and
W1, X1 and Y1 are each independently hydrogen, (C1 -C2)alkyl, (C1 -C2)alkoxy, (C1 -C2)alkylthio, bromo, chloro, fluoro, trifluoromethyl, hydroxy, formyl, carboxamido, (C1 -C2)alkylcarboxamido, di(C1 -C2)alkylcarboxamido, cyano, nitro, amino, (C1 -C2)alkylamino or di(C1 -C2)alkylamino.
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Abstract
Certain substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones are highly potent gabaergic agents, valuable in the treatment of individuals suffering from schizophrenia or reversing the side effects of a previously or concurrently administered neuroleptic agent; or in the treatment of epilepsy. A wider class of substituted 1-phenyl-3-(aminoalkylidene)-2(1H,3H)-indolones, together with 1-phenyl-3-(2-pyrrolidinylidene)-2(1H,3H)-indolones, and homologs thereof, are valuable in the treatment of anxiety.
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Citations
6 Claims
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1. A compound of the formula ##STR8## wherein, A1 is hydrogen or methyl;
- and B and C together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine, morpholine or imidazole ring;
W is hydrogen, (C1 -C2)alkyl, (C1 -C2)alkoxy, chloro, or fluoro; and W1, X1 and Y1 are each independently hydrogen, (C1 -C2)alkyl, (C1 -C2)alkoxy, (C1 -C2)alkylthio, bromo, chloro, fluoro, trifluoromethyl, hydroxy, formyl, carboxamido, (C1 -C2)alkylcarboxamido, di(C1 -C2)alkylcarboxamido, cyano, nitro, amino, (C1 -C2)alkylamino or di(C1 -C2)alkylamino. - View Dependent Claims (2, 3, 4, 5, 6)
- and B and C together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine, morpholine or imidazole ring;
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Current AssigneePfizer Inc.
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Original AssigneePfizer Inc.
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InventorsHoward, Harry R. Jr., Sarges, Reinhard
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Primary Examiner(s)Raymond, Richard L.
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Assistant Examiner(s)Morris, Patricia L.
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Application NumberUS06/641,071Time in Patent Office1,840 DaysField of Search544/144, 546/201, 548/336, 548/468, 548/486, 514/821US Class Current544/144CPC Class CodesC07C 43/225 containing halogenC07D 209/08 with only hydrogen atoms or...C07D 209/34 in position 2C07D 209/38 in positions 2 and 3, e.g. ...
