Methods and apparatus for monitoring cardiovascular regulation using heart rate power spectral analysis

• US 4,862,361 A
• Filed: 06/05/1985
• Issued: 08/29/1989
• Est. Priority Date: 06/05/1985
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Tu, Jerome C., Akselrod, Solange, Burns, Stephen K., DeLeon, Victoria H., Cohen, Richard J., Gordon, David
• Primary Examiner(s): Smith, Jerry
• Assistant Examiner(s): Tbui, Kimthanh
• Application Number:
  US06/742,114
• Time in Patent Office: 1,546 Days
• Field of Search: 364/415, 128/663, 128/661, 128/713, 128/715, 128/702, 128/703
• US Class Current: 600/450
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats

Abstract

Malfunctions of the cardiovascular control system may be diagnosed by examination of a patient'"'"'s heart rate fluctuation power spectra. Particularly indicative of cardiovascular stress are: a level below about 0.1 (beats/min.)² in the power spectrum of heart rate fluctuations at a frequency between about 0.04 and about 0.10 Hz; a marked increase to above about 10 (beats/min.)² in a peak in the heart rate fluctuation power spectrum between about 0.04 to 0.10 Hz; and a ratio of the area under a heart rate power spectrum peak at a frequency between about 0.04 and 0.10 Hz to the area under a peak in the respiratory heart rate fluctuation power spectrum centered at the mean respiratory rate about about 0.10 Hz as having an absolute value less than 2.0 for longer than or equal to about one hour or as having an absolute value greater than about 50.

Claims

1. A method for diagnosis of malfunctions of the cardiovascular control system in a patient comprising the steps of:

monitoring a power spectrum of heart rate fluctuations in the patient; and

identifying a level below 0.1 (beats/min)² in the power spectrum of heart rate fluctuations at a frequency between 0.04 and 0.10 Hz as indicative of cardiovascular instability.

2. A method for diagnosis of malfunctions of the cardiovascular control system in a patient comprising the steps of:

monitoring a power spectrum of heart rate fluctuations in the patient; and

identifying a marked increase above 10 (beats/min.)² in a peak in the heart rate fluctuation power spectrum at a frequency between 0.04 to 0.10 Hz as indicative of cardiovascular stress.

3. A method for diagnosis of malfunctions of the cardiovascular control system in a patient comprising the steps of:

monitoring a power spectrum of heart rate fluctuations in the patient; and

identifying a ratio of the area under a heart rate power spectrum peak at a frequency between 0.04 and 0.1 Hz to the area under a peak in the respiratory heart rate fluctuation power spectrum centered at the mean respiratory rate as having an absolute value less than 2.0 for longer than or equal to one hour as indicative of cardiac instability.

4. A method for diagnosis of malfunctions of the cardiovascular control system in a patient comprising the steps of:

monitoring a power spectrum of heart rate fluctuations in the patient; and

identifying a ratio of the area under a heart rate power spectrum peak at a frequency between 0.04 and 0.1 Hz to the area under a peak in the respiratory heart rate fluctuation power spectrum centered at the mean respiratory rate as having an absolute value greater than or 50 as indicative of cardiovascular stress.