Dosage form with improved delivery capability

• US 4,863,456 A
• Filed: 02/08/1988
• Issued: 09/05/1989
• Est. Priority Date: 04/30/1986
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Wong, Patrick S. L., Stephens, Sally I.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Colosimo, Mark F.
• Application Number:
  US07/153,306
• Time in Patent Office: 575 Days
• Field of Search: 604/890-897, 424/489-494, 424/464, 424/422, 424/438
• US Class Current: 604/892.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.

Claims

1. A dosage form for delivering a beneficial agent to the fluid environment of use, comprising:

(a) a wall in at least a part a semipermeable composition permeable to the passage of an exterior fluid and substantially impermeable to the passage of a beneficial agent, which wall surrounds and forms;

(b) a compartment;

(c) a first layer comprising a beneficial agent in the compartment, which layer forms in situ a dispensable aqueous formulation comprising the beneficial agent with aqueous fluid that enters the compartment;

(d) a third layer comprising hydrogel means for expanding and occupying space in the presence of fluid in the compartment;

(e) a second layer pressed laminated into laminar arrangement between the first and third layer in the compartment, said second layer comprising a thickness of 1 to 7 mm and a permeability constant not more than about 1.0×

10^-5 cm² /hr and being a separate and distinct layer comprising a different composition than the first and third layers, which second layer comprises a non-expandable hydrophobic composition that is a means for substantially preventing the migration of the beneficial agent from the first layer comprising the dispensable aqueous formulation into the third layer; and

,

(f) means in the wall connecting the exterior of the dosage form with the compartment.

2. The dosage form for delivering the beneficial agent to a fluid environment of use according to claim 1, wherein the means connecting the exterior of the dosage form with the internal compartment comprises at least one passageway.

3. The dosage form for delivering the beneficial agent to a fluid environment of use according to claim 1, wherein the beneficial agent is chlorpheniramine.

4. The dosage form for delivering the beneficial agent to a fluid environment of use according to claim 1, wherein the means for connecting the exterior of the dosage form with the interior compartment is a microporous member.

5. The dosage form for delivering the beneficial agent to a fluid environment of use according to claim 1, wherein the means in the wall connecting the exterior of the dosage form with the compartment is a passageway pore formed by leaching a material from the wall.