Fabric and method of use for treatment of scars

• US 4,865,031 A
• Filed: 10/03/1988
• Issued: 09/12/1989
• Est. Priority Date: 07/12/1985
• Status: Expired due to Fees

• Current Assignee: O'Keeffe, Paul J.
• Original Assignee: O'Keeffe, Paul J.
• Inventors: O'Keeffe, Paul J.
• Primary Examiner(s): Coven, Edward M.
• Assistant Examiner(s): Jackson, Gary
• Application Number:
  US07/253,953
• Time in Patent Office: 344 Days
• Field of Search: 128/334, 128/335.5, 128/156
• US Class Current: 606/151
• CPC Class Codes: A61B 17/04 for suturing wounds; Holders or packages for needles or suture materials suture materials A61L17/00
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/105 Skin implants, e.g. artificial skin
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2210/0004 bioabsorbable

Abstract

The present invention discloses a mesh like fabric for implantation beneath or within the dermis to control formation of scar tissue; the fabric being aligned such that its axis having the greatest resistance to distension is aligned parallel to the predominant stresses to which a wound is thought to be subject these being principally parallel to the wound line; axes of the fabric having lesser resistances to distension serving to control other stresses within the dermis transverse to the predominant longitudinal stresses; the fabric being provided with a binder in order to maintain the mesh structure in a known pre-stressed orientation.

Claims

1. A soft, fine, bio-compatible, long term bio-degradable mesh-like fabric fixed by a bio-compatible binder in a pre-stressed state such that the fabric is relatively resistant to distension along one axis of its surface as compared to at least one other such non parallel axis;

wherein the binder is adapted to lose its rigidity soon after, but not immediately upon, contact with body fluids.

2. A fabric as claimed in claim 1 manufactured from long-term biodegradable silk thread of between 0.009 mm to 0.2 mm diameter.

3. A fabric as claimed in claim 1 being formed as a tulle having apertures of between 0.01 mm and 5 mm wide.

4. A fabric as claimed in claim 1 being tricot knit with apertures of between 0.01 and 0.5 mm wide.

5. A fabric as claimed in claim 1 wherein the binder is a light coating of dried gelatin or collagen.

6. A fabric as claimed in claim 1 wherein the binder is a light coating of gelatin or collagen, the gelatin or collagen being cross linked to the extent that the binder maintains its rigidity at least until the fabric is implanted and the action of body fluids on the binder softens the binder.

7. A fabric as claimed in claim 1 wherein the gelatin binder is applied to one side only of the fabric and an additional layer of more heavily cross linked gelatin is applied over the binder in order to prevent curling of the fabric when it is applied sub-dermally, the extent of cross linking of the additional layer being adequate to resist immediate expansion of the binder upon exposure to body fluids.

8. A fabric in accordance with claim 1 wherein there are provided two layers of fabric with a binder of gelatin or collagen;

the binder being predominantly disposed between the two layers of fabric and cross linked to the extent that when used intradermally, contact between body fluids and the binder causes expansion in the binder which urges each layer of fabric against the dermis;

the binder serving to attract fibroblasts from the dermis through each layer of fabric.

9. A fabric in accordance with claim 1 wherein the configuration of the fabric is a flattened tube with a binder of gelatin or collagen, the binder being predominantly disposed within the tubular structure and cross linked to the extent that when used intradermally, contact between body fluids and the binder causes expansion of the binder which urges the fabric against the dermis, the binder serving to attract fibroblasts from the dermis through each layer of fabric.

10. A fabric in accordance with claim 1 hereof wherein the fabric/binder unit is coated with an oil in order to retard the softening action exerted by the body fluids on the binder at least until the surgeon has completed the implant.

11. A fabric in accordance with claim 1 hereof wherein the fabric/binder unit is coated with vitamin E oil in order to retard the softening action exerted by the body fluids on the binder at least until the surgeon has completed the implant.

12. A fabric in accordance with claim 1 in combination with a sheath, wherein the fabric is incorporated in the sheath which is adapted to be temporarily partially implanted in a wound;

the sheath being sufficiently rigid to prevent curling, buckling or bunching of the fabric; and

the sheath being adapted to prevent contact between body fluids and at least a substantial portion of the fabric and adapted for removal from about the fabric prior to closing of the wound.

13. A fabric in accordance with claim 1 in combination with a sheath, wherein the fabric is incorporated in the sheath which is adapted to be temporarily partially implanted in a wound;

the sheath being sufficiently rigid to prevent curling, buckling or bunching of the fabric;

the sheath adapted to prevent contact between body fluids and at least a substantial portion of the fabric and adapted for removal from about the fabric prior to closing of the wound;

a bio-compatible oil being interposed between the fabric and the sheath as a lubricant to assist removal of the sheath from about the fabric.

14. A fabric in accordance with claim 1 in combination with a sheath, wherein the fabric is incorporated in a stiff nylon transparent sheath;

the sheath being sufficiently rigid to prevent curling, buckling or bunching of the fabric;

the sheath adapted to prevent contact between body fluids and at least a substantial portion of the fabric and adapted for removal from about the fabric prior to the closing of the wound.

15. A fabric in accordance with claim 13 wherein the bio-compatible oil is Vitamin E oil.

16. A method for sub-dermally or intradermally implanting a fabric to control formation of scar tissue which comprises implanting a bio-compatible, long-term bio-degradable mesh-like fabric which is fixed by a temporary bio-compatible binder in a pre-stressed state, said fabric being non-distensible along one axis as compared with its distensibility along at least one other non-parallel axis, into or just under the dermis proximate the wound in such a manner that the relatively non-distensible axis of the fabric is parallel to the suspected primary stress carrying axis within the dermis.