Method for rendering a substrate surface antithrombogenic
First Claim
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1. A method for heparinizing a polymeric substrate comprising:
- (a) adjusting the pH of a solution of a surface active agent of the ammonium salt type in a solvent to above 7.5, said surface active agent having at least one alkyl group of 8 to 20 carbon atoms;
(b) steeping a polymeric substrate in said solution of adjusted pH whereby a coating of said surface active agent forms on said substrate;
(c removing said substrate having said coating from said solution of adjusted pH; and
(d) immersing said substrate having said coating in a solution of heparin whereby said heparin reacts with said coating of surface active agent to give a heparinized substrate.
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Abstract
A method for heparinizing a substrate includes applying a coating of ammonium salt to a substrate by steeping the substrate in a solution of the salt at an alkaline pH and contacting the coated substrate with a solution of a salt of heparin.
77 Citations
21 Claims
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1. A method for heparinizing a polymeric substrate comprising:
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(a) adjusting the pH of a solution of a surface active agent of the ammonium salt type in a solvent to above 7.5, said surface active agent having at least one alkyl group of 8 to 20 carbon atoms; (b) steeping a polymeric substrate in said solution of adjusted pH whereby a coating of said surface active agent forms on said substrate; (c removing said substrate having said coating from said solution of adjusted pH; and (d) immersing said substrate having said coating in a solution of heparin whereby said heparin reacts with said coating of surface active agent to give a heparinized substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for rendering a substrate antithrombogenic comprising:
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(a) adjusting the pH of a dispersion of a surface active agent of the ammonium salt type in a solvent to above 7.5; (b) steeping a substrate in said solution of adjusted pH thereby causing a coating of said surface active agent to form on said substrate; (c) removing said substrate having said coating thereon from said solution of adjusted pH; and (d) immersing said substrate having said coating thereon in a solution of a sulfonated polysaccharide whereby said polysaccharide reacts with said coating of surface active agent to give an antithrombogenic substrate. - View Dependent Claims (15)
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16. A method for heparinizing a polymeric substrate comprising:
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(a) adjusting the pH of a solution of dodecylmethylammonium chloride in aqueous medium by adding a sufficient quantity of an alkalinizing agent to raise the pH of said solution to about 10.2; (b) steeping a polymeric substrate in said solution of pH about 10.2 whereby a coating of dodecylmethylamine forms on said substrate; (c) removing said substrate having said coating from said solution of pH about 10.2; and (d) immersing said substrate having said coating in a solution of heparin, said heparin reacting with said coating to give a heparinized substrate. - View Dependent Claims (17, 18, 19, 20, 21)
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Specification