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Protein adsorbent including a colored compound containing a quaternary ammonium especially amidinium or guanidimium cationic group and a cellulose reactive group

  • US 4,865,990 A
  • Filed: 07/09/1987
  • Issued: 09/12/1989
  • Est. Priority Date: 07/15/1985
  • Status: Expired due to Fees
First Claim
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1. A protein adsorbent suitable for use in the chromatographic separation of complex biological molecules which comprises a coloured compound having the formula:

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    space="preserve" listing-type="equation">A--Y--Bor,
    
    
    space="preserve" listing-type="equation">Y'"'"'--Bwherein A is a cationic group selected from (i) an acyclic or cyclic fully substituted ammonium group of the formulae;

    ##STR4## wherein R1 to R4 are alkyl, alkenyl or aryl groups, B represents an aromatic radical and D represents an alicyclic radial in which at least one of R1 or R4, B and D contains a free valency, and (ii) an amidinium or guandiinium group of the formula;

    ##STR5## wherein R6 to R9 are H or alkl, alkenyl or aryl groups and n is 0 or 1;

    Y is a chromophore;

    Y'"'"' is a cationic chromophore; and

    B is a mono- or poly-halogenoheterocycle selected from dichloropyrimidinyl, difluoropyrimidinyl, trichloropyrimidinyl, 5-chlorodifluoropyrimidinyl, 5-cyanodichloropyrimidinyl, dichlorotriazinyl and monochlorotriazinyl bound to an inert substrate.

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