Retrograde perfusion

• US 4,867,742 A
• Filed: 08/07/1987
• Issued: 09/19/1989
• Est. Priority Date: 06/06/1986
• Status: Expired due to Term

• Current Assignee: Reynaldo Calderon
• Original Assignee: Reynaldo Calderon
• Inventors: Calderon, Reynaldo
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Costantino, Mario
• Application Number:
  US07/083,673
• Time in Patent Office: 774 Days
• Field of Search: 128/1 R, 128/1.1, 128/328, 128/334 R, 128/654-656, 128/658, 604/4, 604/8, 604/9, 604/27, 604/28, 604/35, 604/38, 604/40, 604/41, 604/43, 604/49, 604/52, 604/53, 604/93, 604/96, 604/101, 604/118, 604/121, 604/151, 604/264, 604/284, 600/3, 600/4
• US Class Current: 604/28
• CPC Class Codes: A61M 1/3615 Cleaning blood contaminated by local chemotherapy of a body part temporarily isolated from the blood circuit
• CPC Class Codes: A61M 2025/09183 having tools at the distal tip
• CPC Class Codes: A61M 2025/1015 having two or more independently movable balloons where the distance between the balloons can be adjusted, e.g. two balloon catheters concentric to each other forming an adjustable multiple balloon catheter system
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61M 25/0026 Multi-lumen catheters with stationary elements catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04

Abstract

Tumors in the body of a patient are studied in situ by a monitor, such as computer assisted tomography, X-ray or the like, while optimal flow paths through the tumor area are established. A catheter with a suction lumen and an infusion lumen, with seals associated with each, is placed in the patient'"'"'s vein near the tumor. Flow is then sealed in the vein with the infusion seal. A carrier medium dye is injected into the tumor at selected flow rates and differential pressures. Flow of the dye through the tumor is observed on the monitor to determine optimal retrograde perfusion paths through the tumor for the selected flow rates and differential pressures. Once the optimal perfusion paths are noted, microspheres with active ingredients, such as chemotherapy, can be selectively perfused through each of the paths in the tumor at desired flow rates, pressures and active ingredient dosages. Alternatively, microspheres with different active ingredients can be selectively introduced through the tumor in different paths at desired active ingredient dosages and established flow rates and pressures.

Claims

1. An apparatus for treating a tumor in the body of a patient with an active ingredient, comprising:

(a) catheter means for location in a vein of the patient near the tumor, said catheter means comprising;

(1) a suction lumen for removing fluids; and

(2) an infusion lumen extending beyond said suction lumen for passing fluids into the tumor;

(b) infusion seal means on said catheter means between said infusion lumen and said suction lumen for sealing the patient'"'"'s vein;

(c) suction seal means on said catheter means for sealing the flow of fluid in the patient'"'"'s vein past said suction lumen.

(d) a source of carrier medium and a flow path injector means for injecting said carrier medium into the tumor from said infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor;

(e) a source of active ingredient and a treatment injector means for injecting said active ingredient into the patient'"'"'s vein from said infusion lumen at one of the selected flow rates and pressures so that the active ingredient may perfuse through the tumor along one of the preferential flow paths established by said flow path injector means; and

(f) means for collecting the active ingredient from said suction lumen after perfusion through the tumor.

2. The apparatus of claim 1, wherein said treatment means further comprises:

means for varying the flow rate and pressure of injection of the active ingredient into the patient'"'"'s tumor to establish distinct differential flow paths therethrough.

3. The apparatus of claim 1, wherein said treatment means further comprises:

means for selectively injecting different active ingredients into the patient'"'"'s vein at different flow rates and pressures so that the different active ingredients may perfuse through the tumor along distinct preferential flow paths.

4. The apparatus of claim 1, wherein said treatment means further comprises:

means for selectively injecting different active ingredients into the patient'"'"'s vein at different flow rates and pressures so that the different active ingredients may perfuse through the tumor along distinct preferential flow paths at different times.

5. A method for treating a tumor in the body of a patient with an active ingredient, comprising the steps of:

(a) placing a catheter having a suction lumen, an infusion lumen extending beyond the suction lumen, and an infusion seal between same in a vein of the patient near the tumor;

(b) sealing the flow of fluid in the patient'"'"'s vein between the infusion lumen and the suction lumen with the infusion seal;

(c) sealing the flow of a fluid in the patient'"'"'s vein past the suction lumen with a suction seal;

(d) injecting a carrier medium into the tumor from the infusion lumen at selected flow rates and pressures to establish preferential flow paths through the tumor;

(e) injecting an active ingredient into the patient'"'"'s vein from the infusion lumen at one of the selected flow rates and pressures so that the active ingredient may perfuse through the tumor along one of the preferential flow paths established during said step of injecting; and

(f) collecting the active ingredient in the suction lumen after perfusion through the tumor.

6. The method of claim 5, further including the step of:

collecting the injected carrier medium after said step of injecting same.

7. The method of claim 6, wherein:

said step of collecting the carrier medium is performed after said step of sealing the flow of fluid past the suction lumen.

8. The method of claim 7, wherein:

said step of collecting the carrier medium comprises collecting the carrier medium in the suction lumen.

9. The method of claim 8, further including the step of:

moving the suction lumen to different positions in the patient'"'"'s tumor for each of the selected flow rates and pressures to conform to the flow paths established through the tumor.

10. The method of claim 6, wherein:

said step of collecting the active ingredient is performed after said step of sealing the flow of fluid past the suction lumen.

11. The method of claim 5, further including the steps of:

varying the flow rate and pressure of injection of the active ingredient into the patient'"'"'s tumor to establish distinct differential flow paths therethrough.

12. The method of claim 5, further including the steps of:

selectively injecting different active ingredients into the patient'"'"'s vein at different flow rates and pressures so that the different active ingredients may perfuse through the tumor along distinct preferential flow paths.

13. The method of claim 5, further including the steps of:

selectively injecting different active ingredients into the patient'"'"'s vein at different flow rates and pressures so that the different active ingredients may perfuse through the tumor along distinct preferential flow paths at different times.