Low pH shampoo containing climbazole

• US 4,867,971 A
• Filed: 04/22/1988
• Issued: 09/19/1989
• Est. Priority Date: 04/22/1988
• Status: Expired due to Fees

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: Ryan, Joyce, Stansfield, Malcolm
• Primary Examiner(s): Schofer, Joseph L.
• Assistant Examiner(s): Pili-Curtis, C.
• Application Number:
  US07/185,583
• Time in Patent Office: 515 Days
• Field of Search: 424/78, 424/81, 514/399, 514/852
• US Class Current: 514/399
• CPC Class Codes: A61K 8/4946 Imidazoles or their condensed derivatives, e.g. benzimidazoles
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair

Abstract

A stable homogeneous liquid antidandruff shampoo comprising about 0.10 to 2.0% by weight of 1-imidazolyl-1-(4-chlorophenoxy)-3,3-dimethylbutan-2-one (Climbazole) solubilized in an aqueous vehicle containing an acidic surfactant system of about pH 4 to pH 5.5 and further comprising a major amount of an anionic surfactant and minor amounts of either a nonionic, cationic, or amphoteric surfactant or a mixture thereof.

Claims

1. A homogenous liquid antidandruff shampoo composition comprising about 0.1-2.0% by weight of 1-imidazolyl-1-(4-chlorophenoxy)-3,3-dimethylbutan-2-one (Climbazole) solubilized in an aqueous vehicle containing a low pH surfactant system which is adjusted with an agent to about pH 4 to 5, said surfactant system comprising an anionic surfactant as the primary surfactant and minor amounts of a supplemental surfactant selected from the group consisting of nonionic, amphoteric, and cationic surfactants and mixtures thereof.

2. The composition according to claim 1, wherein the aqueous vehicle constitutes about 70-95% by weight.

3. The composition according to claim 2, wherein the anionic surfactant constitutes about 6-25% by weight and the supplemental surfactant or mixture of surfactants constitutes about 1-7% by weight.

4. The composition according to claim 3, wherein the surfactant system comprises a combination of anionic and nonionic surfactants in a weight ratio of 14/3, anionic/nonionic surfactant.

5. The composition according to claim 3, wherein the surfactant system comprises a combination of anionic and amphoteric surfactants in a weight ratio of 8/2, anionic/amphoteric surfactant.

6. The composition according to claim 3, wherein the surfactant system comprises a combination of anionic, amphoteric and cationic surfactants in a weight ratio of 8/2/0.2, anionic/amphoteric/cationic surfactant.

7. The composition according to claim 3, wherein the surfactant system comprises a combination of anionic, nonionic, amphoteric and cationic surfactants in a weight ratio of 8/1/1/0.1, anionic/nonionic/amphoteric/cationic surfactant.

8. The composition according to claim 5, additionally containing triethanolamine myristate.

9. The composition according to claim 3, wherein the anionic surfactant is a water soluble sulfate or sulfonate salt having an alkyl radical of 10-18 carbon atoms.

10. The composition according to claim 9, wherein the anionic surfactant is represented by the formula:

space="preserve" listing-type="equation">R.sub.1 --O(CH.sub.2 CH.sub.2 O).sub.n SO.sub.3 M,

wherein R₁ is an alkyl radical having 10-18 carbon atoms, n is an integer having a value of 0-5, and M is an alkali metal, ammonium, alkylol ammonium or an organic amine.

11. The composition according to claim 10, wherein the anionic surfactant is sodium lauryl ethenoxy ether sulfate containing 2-ethoxy radicals per molecule.

12. The composition according to claim 4, wherein the nonionic supplemental surfactant is a mono- or di-ethanolamide of a higher fatty acid having 8 to 18 carbon atoms, in an amount of about 1-5% by weight.

13. The composition according to claim 12, wherein the nonionic surfactant is cocodiethanolamide.

14. The composition according to claim 5 wherein the amphoteric surfactant is selected from the group consisting of betaines, sulfobetaines, amidobetaines, amidosulfobetaines and mixtures thereof, in an amount of about 1-5% by weight.

15. The composition according to claim 14, wherein the amphoteric surfactant is cocoamidopropyl betaine.

16. The composition according to claim 3, wherein the cationic surfactant is a polymeric quaternary ammonium salt consisting of acrylamide and dimethyl diallyl ammonium chloride monomers, in an amount of about 0.05-0.5% by weight.

17. The composition according to claim 4, containing 1% Climbazole and having a pH 4.

18. The composition according to claim 4 containing 2% Climbazole and having a pH 4.

19. A method of removing dandruff from the scalp and hair comprising shampooing with the liquid composition of claim 1 at least twice weekly.

20. A composition according to claim 1, wherein the agent for adjusting the pH is a strong base.

21. A composition according to claim 1, wherein the agent for adjusting the pH is a strong acid.