24,24-difluoro-26,27-dimethylvitamin D.sub.3 derivatives

• US 4,868,165 A
• Filed: 05/30/1986
• Issued: 09/19/1989
• Est. Priority Date: 05/30/1985
• Status: Expired due to Fees

• Current Assignee: Taisho Pharmaceutical Company Limited (Taisho Pharmaceutical Holdings Company Limited)
• Original Assignee: Taisho Pharmaceutical Company Limited (Taisho Pharmaceutical Holdings Company Limited)
• Inventors: Ikekawa, Nobuo
• Primary Examiner(s): Schenkman, Leonard
• Assistant Examiner(s): Lipovsky, Joseph A.
• Application Number:
  US06/868,741
• Time in Patent Office: 1,208 Days
• Field of Search: 514/167, 260/397.2
• US Class Current: 514/167
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 3/14 for calcium homeostasis vitamin D A61P3/02; parathyroid hormones A61P5/18; calcitonin A61P5/22; osteoporosis A61P19/10; bone metastasis A61P35/04
• CPC Class Codes: C07C 401/00 Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
• CPC Class Codes: C07J 31/006 not covered by C07J31/003
• CPC Class Codes: C07J 9/00 Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
• CPC Class Codes: C07J 9/005 containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Abstract

24,24-Difluoro-26,27-dimethylvitamin D₃ derivatives represented by formula: ##STR1## wherein X represents a hydrogen atom or a hydroxyl group. These compounds are prepared by irradiating 24,24-difluoro-26,27-dimethylcholesta-5,7-diene-(1α,)3β, 25-di- or triol with ultraviolet light, and is useful for the prevention or treatment of, for example, calcium pathobolism or osteoporosis.

Claims

1. A 24,24-difluoro-26,27-dimethyl vitamin D₃ derivative represented by the formula:

##STR8## wherein X represents a hydroxyl group.

2. A pharmaceutical composition for the prevention or treatment of calcium pathobolism or osteoporosis, which comprises an amount, effective for the prevention or treatment of said diseases, of a 24,24-difluoro-26,27-dimethylvitamin D₃ derivative of claim 1, and a pharmaceutically acceptable diluent or carrier.

3. A method for the prevention or treatment of calcium pathobolism or osteoporosis, which comprises administering an effective amount of a 24,24-difluoro-26,27-dimethylvitamin D₃ derivative of claim 1 to a mammal.