Enhancement of prazosin

• US 4,868,182 A
• Filed: 02/03/1988
• Issued: 09/19/1989
• Est. Priority Date: 11/05/1986
• Status: Expired due to Term

• Current Assignee: Aventis Incorporated (Sanofi )
• Original Assignee: Merrell Pharmaceuticals Incorporated (Dow, Inc.)
• Inventors: Dage, Richard C.
• Primary Examiner(s): Robinson, Douglas W.
• Assistant Examiner(s): Henley, III, Raymond J.
• Application Number:
  US07/153,542
• Time in Patent Office: 594 Days
• Field of Search: 514/254, 514/300, 514/303, 514/313, 514/386
• US Class Current: 514/252.05
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

This invention relates to the synergistic enhancement of certain antihypertensives by the conjunctive use of certain cardiotonic agents. More specifically, this invention relates to the enhancement of the blood pressure lowering effect achieved with alpha₁ -adrenoceptor antagonists by the conjunctive administration of cardiotonic agents possessing the ability to specifically inhibit cyclic AMP-phosphodiesterase.

Claims

1. In the treatment of hypertension with a therapeutically effective dose of an alpha₁ -adrenoceptor antagonist selected from the group consisting of prazosin, trimazosin, amiquinsin, leniquinsin and quinazosin, the improvement which comprises the conjunctive administration of at least a threshold dose of a cardiotonic agent, capable of specifically inhibiting cardiac high affinity cyclic AMP-phosphodiesterase, selected from the group consisting of imadazon enoximone, piroximone, amrinone, milrinone, isomazole, pimobendane, and 4,5-dihydro-6-[4-(1H-imidazol-1-yl)-phenyl]-5-methyl-2H-pyridazinone.

2. A method of claim 1 wherein the alpha₁ -adrenoceptor antagonist is prazosin.

3. A method of claim 2 wherein the cardiotonic agent is enoximone.

4. A method of claim 2 wherein the cardiotonic agent is amrinone.

5. A method of claim 2 wherein the cardiotonic agent is 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-5-methyl-(2H)-pyridazinone.

6. A method of claim 2 wherein the cardiotonic agent is piroximone.

7. A method of claim 2 wherein the cardiotonic agent is imadazon.

8. A method of claim 2 wherein the cardiotonic agent is isomazole.