Ionic heparin coating

• US 4,871,357 A
• Filed: 09/14/1987
• Issued: 10/03/1989
• Est. Priority Date: 01/21/1986
• Status: Expired due to Term

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Baxter International Inc.
• Inventors: Tong, Sun D., Hsu, Li-Chien
• Primary Examiner(s): Truluck, Dalton L.
• Application Number:
  US07/097,295
• Time in Patent Office: 750 Days
• Field of Search: 604/266, 604/268, 604/269, 536/21, 514/56
• US Class Current: 604/266
• CPC Class Codes: A61L 33/0017 using a surface active agent

Abstract

A non thrombogenic quarternary ammonium/heparin complex coating for a medical article is disclosed where the organic cationic salt is an alkylbenzyldimethyl ammonium ion present in an amount of at least 50% by weight and having the following formula: ##STR1## where R is a uniform alkyl group containing between 16 to 18 carbon atoms.

Claims

1. A blood contacting medical article comprising:

(a) a substrate polymeric surface; and

(b) an anti-thrombogenic, saline stable surface coating of a complex of heparin and at least 50% by weight of a cationic alkylbenzyl dimethyl ammonium salt having the following formula;

##STR5## where R is an alkyl group having from 16 to 18 carbon atoms.

2. The medical article of claim 1 wherein complex is cetalkonium heparin.

3. The medical article of claim 2 wherein the complex is stearylkonium heparin.

4. The medical article of claim 1 wherein the substrate surface comprises a polymeric resin.

5. The medical article of claim 1 wherein the organic cationic salt is present in an amount of 60 to 70% by weight of the complex composition.

6. A process for rendering the polymeric surfaces of blood contacting medical articles non-thrombogenic comprising:

(a) providing a medical article; and

(b) coating the medical article with a complex of heparin and at least 50%, by weight of an alkylbenzyl dimethyl ammonium cationic salt of the formula;

##STR6## where R is an alkyl group from 16 to 18 carbon atoms.

7. The process of claim 6 wherein the coating step comprises:

(a) providing an organic solution of the heparin complex;

(b) applying the solution to the surface of a medical article; and

(c) drying the medical article to form an integral adhesive coating thereon.

8. A process of claim 6 wherein the coating step comprises:

(a) treating the medical article with a solution of a cationic quarternary ammonium organic salt having the following formula;

##STR7## where R is an alkyl group containing from 16 to 18 carbon atoms and X is a halogen; and

(b) subsequently treating the medical article with an aqueous solution of heparin salt.

9. A blood contacting saline stable coating comprising:

a complex of heparin and at least 50% by weight of a cationic alkylbenzyl dimethyl ammonium salt of the formula;

##STR8## wherein;

R is a C₁₆ to C₁₈ alkyl grouping.

10. The blood contacting article of claim 9 wherein said complex is cetalkonium heparin.

11. The blood contacting article of claim 9 wherein said complex is stearylkonium heparin.

12. The blood contacting article of claim 9 wherein ammonium salt comprises from about sixty to about seventy percent by weight of the complex.