Process for surface modification of inorganic biomaterial

• US 4,871,384 A
• Filed: 04/28/1988
• Issued: 10/03/1989
• Est. Priority Date: 04/28/1987
• Status: Expired due to Fees

• Current Assignee: Hoya Corporation
• Original Assignee: Hoya Corporation
• Inventors: Kasuga, Toshihiro
• Primary Examiner(s): Schor, Kenneth M.
• Application Number:
  US07/187,457
• Time in Patent Office: 523 Days
• Field of Search: 65/30.1, 65/33, 65/60.5, 427/399, 501/5, 501/8, 501/10, 428/704
• US Class Current: 65/30.1
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: C03C 14/004 the non-glass component being in the form of particles or flakes
• CPC Class Codes: C03C 17/22 with other inorganic material C03C17/34, C03C17/44 take precedence
• CPC Class Codes: C03C 2214/04 Particles; Flakes
• CPC Class Codes: C03C 2214/20 Glass-ceramics matrix
• CPC Class Codes: C03C 2217/28 Other inorganic materials
• CPC Class Codes: C03C 2218/11 from solutions or suspensions
• CPC Class Codes: C03C 23/00 Other surface treatment of glass not in the form of fibres or filaments

Abstract

According to the present process for modifying the surface of a biomaterial, there can be precipitated on the surface of a biomaterial a calcium phosphate crystal which is necessary for the biomaterial to form a chemical bonding with human bones. Therefore, the bioactivity of a biomaterial for use as an artifical bone or a dental implant can be improved by the present process.

Claims

1. A process for modifying the surface of a bioactive ceramic-crystallized-glass-composite biomaterial, which comprises providing said biomaterial, as a biomaterial which contains a crystallized glass of at least 12-56% CaO, 1-27% P₂ O₅ and 22-50% SiO₂ and a reinforcing amount of a reinforcing ceramic of zirconia and/or alumina ceramic dispersed in the crystallized glass, contacting said biomaterial with an aqueous solution containing calcium ion and/or phosphate ion to dissolve CaO and/or P₂ O₅ from said biomaterial into said solution and precipitate a calcium phosphate crystal on the surface of said biomaterial, said contacting being effected for sufficient time and temperature to improve bioactivity of the biomaterial and to completely cover the composite biomaterial with calcium phosphate crystal, and removing said composite biomaterial from the aqueous solution as a calcium-phosphate-covered biomaterial with increased bioactivity.

2. A process according to claim 1, wherein the composite is a ceramic-bioactive crystallized glass composite obtained by dispersing a reinforcing ceramic selected from zirconia, alumina and zirconia-alumina ceramic in a bioactive crystallized glass comprising the following components of the following proportions

3. A process according to claim 2, wherein the amount of a reinforcing ceramic dispersed in a bioactive crystallized glass is 5-50% by volume based on the composite.

4. A process according to claim 1, wherein the aqueous solution has a pH of 5 or more.

5. A process according to claim 1, wherein the temperature of the aqueous solution is from 10°

to 200°

C.

6. A process according to claim 1, wherein the treatment is conducted for 1-240 hours.