Ion sensor

• US 4,871,442 A
• Filed: 04/29/1987
• Issued: 10/03/1989
• Est. Priority Date: 05/01/1986
• Status: Expired due to Term

• Current Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Original Assignee: Terumo Corporation
• Inventors: Yamaguchi, Shuichiro, Shimomura, Takeshi, Daikuhara, Norio
• Primary Examiner(s): Niebling, John F.
• Assistant Examiner(s): GORGOS, KATHRYN L
• Application Number:
  US07/044,062
• Time in Patent Office: 888 Days
• Field of Search: 204/416-419
• US Class Current: 204/418
• CPC Class Codes: G01N 27/3335 the membrane containing at least one organic component G01N27/3271 takes precedence; aspects concerning the enzyme reagent in enzyme electrodes C12Q1/001

Abstract

An ion sensor includes an electrically conductive substrate, a redox layer coating the surface of the electrically conductive substrate, a barrier layer coating the surface of the redox layer, and an ion-selective layer coating the surface of the barrier layer. The barrier layer functions to prevent migration between the ion-selective layer and redox layer of substances constituting these layers, and to transmit a potential difference produced in the ion-selective layer by contact with an ion from the ion-selective layer to the redox layer.

Claims

1. An ion sensor comprising:

an electrically conductive substrate;

a redox layer coating a surface of said electrically conductive substrate;

a barrier layer coating a surface of said redox layer; and

an ion-selective layer coating a surface of said barrier layer;

said barrier layer made from a material which functions to prevent mutual contamination between said ion-selective layer and said redox layer with substances constituting these layers, and to transmit a potential produced in said ion-selective layer by contact with an ion from said ion-selective layer to said redox layer.

2. The ion sensor according to claim 1, wherein said material of the barrier layer is selected from a group consisting of a cellulose derivative, a natural aqueous polymer and a semisynthetic aqueous polymer.

3. The ion sensor according to claim 1, wherein said barrier layer has a thickness of 0.2 μ

m-1.0 mm.

4. The ion sensor according to claim 1, wherein said electrically conductive substrate is selected from a group consisting of an electrically conductive carbon material, a metal composite obtained by coating the surface of any of these metals with a semiconductor.

5. The ion sensor according to claim 4, wherein said carbon material comprises basal plane pyrolytic graphite or glassy carbon, said metal comprises gold, platinum, copper, silver, palladium or nickel and said semiconductor comprises iridium oxide or tin oxide.

6. The ion sensor according to claim 1, wherein said redox layer is selected from the group of materials having a redox function.

7. The ion sensor according to claim 1, wherein said redox layer is selected from the group of materials which undergo a quinone-hydroquinone type redox reaction.

8. The ion sensor according to claim 1, wherein said redox layer is selected from the group of materials which undergo an amine-quinoid type redox reaction.

9. The ion sensor according to claim 1, wherein said redox layer is selected from the group of electrically conductive materials consisting of poly (pyrrole) and poly(thienylene).

10. The ion sensor according to claim 1, wherein said redox layer has a thickness of from 0.01 μ

m to 1.0 mm.

11. The ion sensor according to claim 1, wherein said ion-sensitive layer has a thickness of from 1 μ

m to 10 mm.

12. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material, which is a compound expressed by the formula ##STR12## where R¹, R², R³ represent the same or different alkyl groups, among which at least two alkyl groups have a carbon number of 8-18, and is selective to hydrogen ion.

13. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises an organic polymeric membrane containing a an ion carrier material, which is a compound expressed by the formula ##STR13## where R⁴ represents an alkyl group having a carbon number of 8-18, and is selective to hydrogen ion.

14. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material, which is selected from the group consisting of valinomycin, nonactin, monactin, crown ether compounds, and is selective to potassium ion.

15. The ion sensor according to claim 14, wherein said crown either compound comprises dicyclohexyl-18-crown-6, naphto 15-crown-5 or bis(15-crown-5).

16. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material, which is selected from the group consisting of aromatic amides or diamides, aliphatic amides or diamides, and crown compounds, and is selective to sodium ion.

17. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material, which is selected from the group of quaternary ammonium salts expressed by the formula ##STR14## where R⁷, R⁸, R⁹ represent the same or different alkyl groups which have a carbon number of 8-10, and R₁₀ represents hydrogen or an alkyl group having a carbon number of 1-8, and is selective to chloride ion.

18. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material comprising which is selected from triphenyl tin chloride, expressed by the formula ##STR15## and is selective to chloride ion.

19. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material, which is selected from the group consisting of calcium bis(di-(n-octylphenyl) phosphate), (-)-(R,R)-N,N'"'"'-bis{(11-ethoxycarbonyl) undecyl}-N,N'"'"',4,5-tetramethyl-3,6-dioxaoctanediamide and calcium bis(di(n-decyl) phosphate), and is selective to calcium ion.

20. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material, which is selected from the group of quaternary ammonium salts expressed by the formula ##STR16## where R₁₁, R₁₂, R₁₃ represent the same or different alkyl groups having a carbon number of 8-18, R¹⁴ represents hydrogen atom or an alkyl group having a carbon number of 1-4, and X^- represents Cl^-, Br^- or OH^-, and is selective to hydrogencarbonate ion.

21. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material, which is selected from the group of tertiary amine compounds expressed by the formula ##STR17## and is selective to hydrogencarbonate ion.

22. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises a polymeric membrane containing an ion carrier material, which is selected from the group of nonactin consisting of monactin and tetranactin, and is selective to ammonium ion.

23. The ion sensor according to claim 1, wherein said ion-sensitive layer comprises an organic polymeric membrane containing an ion carrier material comprising N, N'"'"'-diheptyl-N,N'"'"'-dimethyl-1,4-butane diamide, and is selective to magnesium ion.