Compositions having antithrombogenic properties and blood contact medical devices using the same

• US 4,872,867 A
• Filed: 02/28/1989
• Issued: 10/10/1989
• Est. Priority Date: 06/19/1985
• Status: Expired due to Fees

• Current Assignee: UBE Industries Limited
• Original Assignee: UBE Industries Limited
• Inventors: Joh, Yasushi
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Rose, Sharon
• Application Number:
  US07/317,108
• Time in Patent Office: 224 Days
• Field of Search: 604/265, 604/266, 604/269, 604/289, 514/822, 427/2, 523/112, 523/113, 525/103, 525/931, 623/1, 623/11
• US Class Current: 604/269
• CPC Class Codes: A61L 33/062 Mixtures of macromolecular compounds
• CPC Class Codes: C08G 2270/00 Compositions for creating interpenetrating networks
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: C08L 75/08 from polyethers
• CPC Class Codes: C08L 83/00 Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

This invention is a composition having anti-thrombogenic properties, comprising as essential constituent components a polyurethane or polyurethane urea containing polytetramethylene oxide in its main chain, a water soluble and/or water swellable macromolecules, and a silicon-containing compound capable of forming polysiloxane while crosslinking; and a blood contact medical device having such a composition on blood contact surfaces. According to this invention, it is possible to provide on blood contact surfaces a hydrophilic polymer which is excellent in dynamic properties and very rich in the antithrombogenic properties, and the invention can be greatly contributory in the field of blood contact medical devices.

Claims

1. An antithrombogenic material having an interpenetrating polymer network which comprises

(1) a polyether type polyurethane or polyurethane urea containing in its main chain a segment comprising polytetramethylene oxide;

(2) a water soluble polymer, a water swellable polymer or a combination thereof; and

(3) a room temerpature cross-linking type silane coupling agent capable of being activated by water and induced condensation polymerization with crosslinking which is crosslinked to form a hydrophobic highly crosslinked polysiloxane network in which network the polyether type polyurethane or polyurethane urea, and the water soluble polymer, the water swellable polymer or combination thereof, are entangled.

2. The composition having antithrombogenic properites as claimed in claim 1, wherein said polymer is a macromolecular compound containing in its backbone, polyalkylene oxide wherein the carbon atom number of alkylene is 2 or 3 or 2 and 3.

3. The composition having antithrombogenic properties as claimed in claim 2, wherein the macromolecular compound containing in its main chain said polyalkylene oxide is a polyether polyurethane comprising polyethylene oxide as a segment.

4. The composition having antithrombogenic properties as claimed in claim 1, wherein the said polymer is a polydimethylsiloxane/polyethylene glycol copolymer.

5. The composition having antithrombogenic properties as claimed in claim 1, wherein the second component is at least one selected from polyvinyl alcohol, polyvinyl pyrrolidone, polyacrylic acid or a salt thereof, polyhydroxyethyl acrylic acid or a salt thereof, atelo collagen, water soluble gelatin, chondroitin sulfuric acid or a salt thereof, hyaluronic acid, alginic acid, water soluble or, oxydized starch (dialdehyde starch, diacetone acrylamide, 2-acrylamide-2-methylpropane sulfonic acid or a salt thereof, and soluble heparin.

6. The composition having antithrombogenic properties as claimed in claim 1, wherein the silicon-coupling agent is at least one selected from methyltriethoxysilane, methyltriacetoxysilane, tetramethoxysilane and tetraacetoxysilane.

8. The composition having antithrombogenic properites as claimed in claim 1 wherein said silane coupling agent contains Si-OCOR or Si-OR wherein R is CH₃, C₂ H₅, C₃ H₇ or C₄ H₉, as functional groups.

9. The composition having antithrombogenic properties as claimed in claim 1 wherein said silane coupling agent contains SiOX or SiX wherein X is halogen, as functional group.

10. The compositon having antithrombogenic properties as claimed in claim 9 wherein X is chlorine or bromine.

11. The composition having antithrombogneic properties as claimed in claim 1 wherein said silane coupling agent contains Si-NR₂ wherein R is CH₃, C₂ H₅, C₃ H₇ or C₄ H₉ as functional groups.

12. The composition of claim 5 wherein the coupling agent is methyltriethoxysilane, methyltriacetoxysilane, tetramethoxysilane or tetraacetoxysilane.

13. The composition of claim 12 wherein said polyether type polyurethane is used.

14. The composition of claim 12 wherein said polyurethane urea is used.

7. A blood contact medical device characterized in that it comprises a blood contact surface constituted of a polyurethane or polyurethane urea having polytetramethylene oxide in its main chain, a water soluble and/or water swellable macromolecules, and a polysiloxane having crosslinked structure.