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Isolation of exogenous recombinant proteins from the milk of transgenic mammals

  • US 4,873,316 A
  • Filed: 06/23/1987
  • Issued: 10/10/1989
  • Est. Priority Date: 06/23/1987
  • Status: Expired due to Term
First Claim
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1. A process for the production and secretion into mammal'"'"'s milk of an exogenous recombinate protein comprising the steps of:

  • a. producing milk in a transgenic mammal characterized by an expression system comprising a casein promoter operatively linked to an exogenous DNA sequence coding for the recombinant protein through a DNA sequence coding for a signal peptide effective in secreting and maturing the recombinant protein in mammary tissue;

    b. collecting the milk; and

    c. isolating the exogenous recombinant protein from the milk.

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