Blood clotting time measuring apparatus

• US 4,876,069 A
• Filed: 10/27/1986
• Issued: 10/24/1989
• Est. Priority Date: 07/11/1981
• Status: Expired due to Term

• Current Assignee: Siegfried Jochimsen
• Original Assignee: Siegfried Jochimsen
• Inventors: Jochimsen, Siegfried
• Primary Examiner(s): Hill, Jr., Robert J.
• Application Number:
  US06/924,155
• Time in Patent Office: 1,093 Days
• Field of Search: 436/69, 435/13, 422/73, 73/64.1, 356/39, 356/442, 366/273, 366/274
• US Class Current: 422/73
• CPC Class Codes: B01F 2101/23 Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
• CPC Class Codes: B01F 33/452 using independent floating stirring elements
• CPC Class Codes: B01F 35/42 Clamping or holding arrangements for mounting receptacles on mixing devices
• CPC Class Codes: G01N 21/03 Cuvette constructions
• CPC Class Codes: G01N 21/82 producing a precipitate or turbidity
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/56

Abstract

Blood clotting time measuring apparatus has a temperature controlled cabinet with at least one measuring channel for receiving a measuring cell (17) containing a blood sample, the clotting time of which is to be measured. The cabinet includes clamping means (18) for retaining the measuring cell in said measuring channel. A magnetic stirrer (16, 16a) is mounted in the cabinet proximate to the measuring channel and has a metal ball (23) positionable in the measuring cell and magnetically operable with the stirrer. A photo optical turbidity detector has a light source (15) and a light detector (14) forming a photo optical path (32) containing the measuring cell. The light source receives an operating voltage which is at least half the rated voltage of said source. The light detector is connected to a measured value means (27) having two threshold value limiting means. In the measuring process, the sensing thresholds are established in accordance with the signal derived from the photo optical path prior to clotting to improve the accuracy of clotting time measurement.

Claims

1. Apparatus for measuring blood clotting time;

said apparatus being suitable for use with a measuring cell having a bottom, the measuring cell containing a blood sample, the clotting time of which is to be measured;

said apparatus comprising;

temperature controlled support means having means defining at least one measuring channel, said measuring channel being capable of receiving the measuring cell containing the blood sample;

magnetic stirring means mounted in said support means proximate to said means defining said measuring channel, said magnetic stirring means including a metal ball positionable at the bottom of the measuring cell when the cell is inserted in said channel, said magnetic stirring means further including a magnetic drive means proximate said means defining said measuring channel, said magnetic drive means being operable to rotate said ball in a circular path about the bottom of the measuring cell;

photo optical turbidity detection means having a light source and a light detector forming a photo optical path containing the measuring cell when the cell is inserted in the channel, said light source being of a type such that, in lower portions of its operating voltage range, a given change in operating voltage results in a greater change in light output than in upper portions of its operating range, said light detector being connected through transmission signal adjustment means to a measured value means having two threshold value limiting means;

voltage supply means for supplying an operating voltage to said light source which is at least half the rated voltage of said source;

computer means coupled to said measured value means; and

display means coupled to said measured value means for displaying visually perceptible information.

2. Apparatus according to claim 1 wherein said support means includes clamping means for retaining the measuring cell in said means defining said measuring channel.

3. Apparatus according to claim 2 wherein said clamping means includes a clamping member biased by spring mean for being pressed against the measuring cell when same is inserted in said means defining said measuring channel.

4. Apparatus according to claim 3 further including means for adjusting the bias applied to said clamping member by said spring means.

5. Apparatus according to claim 1 wherein said support means further includes means defining recesses serving as preheaters.

6. Apparatus according to claim 1 wherein said apparatus is further defined as apparatus for measuring aggregation in a blood sample and wherein said apparatus further includes an adjustable min/max amplifier having its input connected to said light detector and its output connected to a curve tracer, said apparatus including switch means for selectively connecting said light detector to said measured value means or said min/max amplifier.

7. Apparatus according to claim 6 wherein said support means includes a socket for a plug of a connecting cable of said min/max amplifier for connecting said light detector to said amplifier.

8. Apparatus for measuring blood blotting time, said apparatus being suitable for use with measuring cells;

each of said measuring cells having a bottom and containing a blood sample, the clotting time of which is to be measured;

said apparatus comprising;

temperature controlled support means having means defining a recess for receiving block means defining a plurality of measuring channels, said measuring channels being capable of receiving the measuring cells containing the blood samples;

magnetic stirring means mounted in said support means proximate to said block means, said magnetic stirring means including metal balls positionable at the bottom of the measuring cells when the cells are inserted in said channels, said magnetic stirring means further including magnetic drive means proximate said block means operable to rotate said balls in circular paths about the bottoms of the measuring cells;

a plurality of photo optical turbidity detection means, each having a light source and a light detector forming a photo optical path containing a measuring cell when the cells are inserted in said channels, each of said light sources being of a type such that, in lower portions of its operating voltage range, a given change in operating voltage results in a greater change in light output than in upper portions of its operating range, said light detectors being connected to analog-digital converter means, microprocessor means coupled to said analog-digital converter means, said microprocessor being operable by control means and being connected to a data output device for displaying visually perceptible information; and

voltage supply means for supplying an operating voltage to said light sources which is at least half the rated voltage of said sources.

9. Apparatus according to claim 8 wherein said data output device comprises at least one of a printer or a monitor.

10. Apparatus according to claim 8 wherein said control means comprises a touch pad for programming said microprocessor.

11. Apparatus according to claim 8 wherein said support means includes means defining additional recesses for receiving and preheating said block means.

12. Apparatus for measuring blood clotting time, said apparatus being suitable for use with measuring cells;

each of said measuring cells having a bottom and containing a blood sample, the clotting time of which is to be measured;

said apparatus comprising;

temperature controlled support means having means defining a recess for receiving block means defining a plurality of measuring channels, said measuring channels being capable of receiving the measuring cells containing the blood samples;

magnetic stirring means mounted in said support means proximate to said block means, said magnetic stirring means including metal balls positionable at the bottom of the measuring cells when the cells are inserted in said channels, said magnetic stirring means further including magnetic drive means proximate said block means and being operable to rotate said balls in circular paths about the bottoms of the measuring cells;

a plurality of photo optical turbidity detection means, each having a light source and a light detector forming a photo optical path containing a measuring cell when the cells are inserted in said channels, each of said light sources being of a type such that, in lower portions of its operating voltage range, a given change in operating voltage results in a greater change in light output than in upper portions of its operating range, each of said light detectors being connected through a series connected amplifier, transmission signal adjuster, and analogdigital converter means to a microprocessor, said microprocessor being operable by control means and being connected to a data output device or displaying visually perceptible information, each of said amplifiers being connected to the light source associated with the corresponding light detector and to said microprocessor, whereby said microprocessor selectively controls and operates said light sources and light detectors; and

voltage supply means for supplying an operating voltage to said light sources which is at least half the rated voltage of said sources.