Dispenser with dispersing member for delivering beneficial agent

• US 4,876,093 A
• Filed: 07/02/1987
• Issued: 10/24/1989
• Est. Priority Date: 07/02/1987
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Theeuwes, Felix, Wong, Patrick S. L.
• Primary Examiner(s): Swisher, Nancy A. B.
• Application Number:
  US07/069,148
• Time in Patent Office: 845 Days
• Field of Search: 424/438, 424/464, 424/466, 424/473, 424/468, 401/12
• US Class Current: 424/438
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A dispenser is enclosed for delivering a beneficial agent to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising carrier means for housing a beneficial agent, push means for pushing the carrier means from the dispenser and fragmenting means for fragmenting the carrier means as it is pushed from the dispenser.

Claims

1. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:

(a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent;

(b) carrier means in the lumen for administering a beneficial agent to the animal environment of use, said carrier means substantially maintaining its physical and chemical integrity while in the lumen of the dispenser;

(c) a beneficial agent in the carrier means for administering a beneficial agent;

(d) pushing means for occupying an increasing amount of space in the lumen for pushing the carrier means comprising the beneficial agent from the dispenser; and

,

(e) a mouth in the dispenser comprising means for breaking the carrier means from a first size to a second size as the carrier means leaves the dispenser.

2. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent comprises hydrophobic composition.

3. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent comprises a hydrophilic composition.

4. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent bioerodes in an animal environment of use.

5. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent is delivered from the dispenser and is hydrolyzed in the animal environment.

6. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent is delivered from the dispenser and is solubilized in the animal environment.

7. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent dissolves in an animal environment.

8. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means in the lumen for administering the beneficial agent disintegrates in the animal environment.

9. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the carrier means administers the beneficial agent by at least one process comprising diffusion, osmosis, osmotic bursting, solution leaching, solubilization, hydrolysis, enzymatic digestion, displacement and dissolution.

10. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the animal environment of use is a ruminant.

11. The dispenser for administering the beneficial agent formulation to an animal environment of use according to claim 1, wherein the animal environment of use is a human.

12. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:

(a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent;

(b) carrier means in the lumen for administering a beneficial agent to the animal environment of use, said carrier means substantially maintaining its physical and chemical integrity while in the lumen of he dispenser;

(c) a beneficial agent in the carrier means;

(d) push means for occupying an increasing amount of space in the lumen for pushing the carrier means for administering a beneficial agent from the dispenser;

(e) dense means in the lumen for maintaining the dispenser in the animal environment of use over time; and

(f) an opening in the wall of the dispenser for communicating the carrier means for administering the beneficial agent with the environment of use, said opening comprising means for breaking the carrier means into smaller carrier means as the carrier means leaves the dispenser.

13. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:

(a) a wall that surrounds and defines an internal lumen, the wall comprising at least in part a semipermeable composition that is permeable to the passage of fluid and is substantially impermeable to the passage of a beneficial agent;

(b) carrier means in the lumen for housing a beneficial agent formulation, said carrier means maintaining its physical and chemical integrity while the carrier means is in the lumen of the dispenser;

(c) a beneficial agent formulation in the carrier means;

(d) expandable means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen, said expandable means comprising a hydrophilic polymeric composition; and

,

(e) a mouth in the dispenser comprising means for fragmenting the carrier means from its lumen size to a different size as it leaves the dispenser.

14. The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means is serrated.

15. The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means is saw-toothed.

16. The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means is a screen.

17. The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means comprises a cutting edge.

18. The dispenser for administering the beneficial agent formulation according to claim 14, wherein the means for fragmenting the carrier means comprises at least one string formed of naturally occurring or synthetic materials.

19. A dispenser for administering beneficial agent formulation to an animal environment of use, the dispenser comprising:

(a) a wall that surrounds a lumen, the wall comprising a semipermeable composition permeable to the passage of fluid;

(b) carrier means in the lumen for containing a beneficial agent formulation, said carrier means keeping its physical and chemical integrity while the carrier means is in the lumen;

(c) a beneficial agent formulation in the carrier means;

(d) solution means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen, said solution means comprising an osmagent that imbibes fluid into the lumen and forms a solution; and

,

(e) an opening in the dispenser comprising means for fragmenting the carrier means from its lumen size to a fragmented size as the carrier means is pushed from the dispenser.

20. A dispenser for administering a beneficial agent formulation to an animal environment of use, the dispenser comprising:

(a) a wall that surrounds a lumen, the wall comprising a semipermeable composition permeable to the passage of fluid;

(b) carrier means in the lumen for housing a beneficial agent formulation, said carrier means keeping its physical integrity in the lumen;

(c) a beneficial agent formulation in the carrier means;

(d) gas generating means for occupying an increasing amount of space in the lumen for pushing the carrier means from the lumen; and

,

(e) an opening in the dispenser comprising means for fragmenting the carrier means from its lumen size to a fragmented size as the carrier means is pushed from the dispenser.

21. A method for delivering a beneficial agent to an animal, wherein the method comprises:

(a) admitting into an animal a dispensing device comprising;

(1) a wall;

(2) a lume defined by the wall;

(3) a solid matrix in the lumen, which matrix comprises compositional means keeping its physical and chemical integrity while in the lumen;

(4) a beneficial agent in the matrix;

(5) an opening in the wall;

(6) means in the opening for changing the matrix from a first size to a second size;

(7) means in the lumen for pushing the matrix through the opening;

(b) pushing the matrix through the opening for changing it from a first to a second size;

thereby,

(c) delivering the beneficial agent to the animal over time.