Method and apparatus of automatic continuous analysis using analytical implement

• US 4,876,204 A
• Filed: 10/01/1985
• Issued: 10/24/1989
• Est. Priority Date: 10/11/1984
• Status: Expired due to Term

• Current Assignee: Kabushiki Kaisha Kyoto Daiichi Kagaku
• Original Assignee: Kabushiki Kaisha Kyoto Daiichi Kagaku
• Inventors: Yamamoto, Hiroshi, Kishimoto, Shinichi, Inoue, Kazushige, Hyodo, Hiroshi
• Primary Examiner(s): Marcus, Michael S.
• Application Number:
  US06/782,356
• Time in Patent Office: 1,484 Days
• Field of Search: 422/63, 422/64, 422/65, 436/47, 436/48, 414/222, 414/225, 414/223, 901/17, 221/171, 221/173, 221/236
• US Class Current: 436/46
• CPC Class Codes: G01N 2035/00039 Transport arrangements specific to flat sample substrates, e.g. pusher blade
• CPC Class Codes: G01N 2035/00049 for loading/unloading a carousel
• CPC Class Codes: G01N 2035/00089 Magazines
• CPC Class Codes: G01N 2035/00108 Test strips, e.g. paper
• CPC Class Codes: G01N 2035/00118 for multiple tests
• CPC Class Codes: G01N 2035/1025 Fluid level sensing
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: Y10T 436/112499 with sample on test slide
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line

Abstract

An autonomous continuous analysis method and apparatus using Dip and Read type analytical implements. A series of operations of taking out analytical implements, dipping them in the sample solution, optical measurement, calculation, and disposal of the used sample solution are performed automatically.

The dip stage, in particular, is automated by use of an analytical-implement automatic supply device and an analytical implement automatic handling device which, holding an analytical implement, dips it in the sample solution, and sets it ona reaction turntable. A number of analytical implements are put in a storage section comprising a bottom section provided with an analytical implement groove and at least one inside surface which is parallel with the groove, are taken out one by one by the relative movement of the groove and in normal and reverse direction and by stopping in a specified position after confirming by a detector that an implement has been caught in the groove.

Claims

1. An automatic continuous analysis method using an analytical implement having a reagent section, comprising:

a transfer process and a measuring process, said transfer process including the steps of supplying analytical implements one by one from an automatic supply device, holding each analytical implement supplied by the automatic supply device by an analytical-implement automatic handling device, moving each analytical implement to a position above a sample vessel which is successively brought into a specified position where each analytical implement is to be dipped into the sample vessel, dipping each analytical implement in a sample solution in the sample vessel and pulling it up after a specified time, moving each implement above a reaction turntable and setting it on the reaction turntable and releasing each analytical implement from the analytical-implement automatic handling device, said measuring processing including the step of automatically measuring, after a specified time, light reflectance of the reagent section of each analytic implement.

2. The continuous automatic analysis method of claim 1, wherein said holding step is effected by holding each analytical implement by a gripping member of a driving arm associated with the analytical implement automatic handling devices.

3. An automatic continuous analysis method using an analytical implement with a reagent section as claimed in claim 1, including the steps of measuring the liquid level of the sample solution in the sample vessel prior to dipping the reagent section of each analytical implement and determining the depth of dipping each analytical instrument according to the liquid level.

4. In the continuous automated analysis method of claim 1, an automatic method of taking out analytical implements for said supplying step including the steps of putting many analytical implements in a storage section comprising a bottom section provided with an analytical implement groove and an inside wall surface which is parallel with the groove, moving said groove in normal and reverse directions relative to the wall surface while checking for the presence of an analytical implement in the groove by a detector on the wall surface, and stopping said movement at a specified position after ascertaining that an analytical implement has been fitted in the groove.

5. The continuous automated analysis method of claim 4 wherein the automatic method of taking out analytical implements includes, by utilizing an inversion device, the steps of pushing out an analytical implement which has been fitted into the groove in a reversed bottom-top direction, inverting the analytical implement towarad the wall and refitting it into the groove while the bottom section goes back in reverse direction.

6. The continuous automated analysis method of claim 4 wherein the automatic method of taking out analytical implements includes, the steps of removing it, by a removing device in the stop position or vicinity, by pushing it out toward the direction opposite to the wall.

7. The continuous automated analysis method of claim 4, wherein the automatic method of taking out analytical implements, includes, when an analytical implement fitted into the groove is a non-conforming one, removing it from the groove and returning it into the hopper and taking out another analytical implement to be caught by the groove.

8. An automatic continuous analysis apparatus for use with an analytical implement having a reagent section, said apparatus comprising an automatic handling section, a control section and a keyboard and display section, said automatic handling section including:

an analytical-implement automatic handling device;

an analytical-implement automatic supply device provided with a hopper into which analytical implements to be put, a sample-vessel supply device, and an optical measurement device being arranged around said analytical-implement automatic handling device;

said hopper including a bottom section provided with a groove for accommodating an analytical implement and wall sections, one of which is parallel with the groove viewed in a plane at least at a lower edge of the inside surface of the wall; and

said bottom section being separated from said wall section and wherein at least a part of the bottom section can advance and return relative to the wall section so that at least said groove can reach positions both inside and outside of the wall section;

said control section controlling the rotation of motors for making the analytical-implement holder move to an analytical-implement take-out position of the analytical-implement automatic supply device and to a position for putting each analytical implement into the turntable groove on the optical measurement device, successively;

the control section also controlling the action of the analytical-implement automatic handling device, the sample-vessel supply device, and the turntable and the light measuring section on the optical measurement device; and

said keyboard and said display section exchanging signals with the control section.

9. An automatic continuous analysis apparatus using an analytic implement as claimed in claim 8, including a detector, which is provided on or near the wall section on the side where the analytical implement groove passes, for detecting an analytical implement caught by the groove.

10. An automatic continuous analysis apparatus using an analytical implement having a reagent section comprising:

an analytical implement automatic supply device;

a sample vessel supplying device;

an analytical implement handling device which is provided with an analytical implement holder on an end of an arm capable of being driven right-and-left, up-and-down, and rotatingly;

a light measuring device including a reaction turntable for providing measured data;

means for controlling the operation of said apparatus by directing the analytical implement holder to successively move to a take-out position of the analytical implement automatic supply device, an analytical implement dipping position of the sample vessel supply device and an analytical implement mounting position of the light measuring device and for controlling the drive of the analytical implement automatic handling device, the sample vessel supplying device, the reaction table of the light measuring device and the light measuring device; and

a display section cooperating with said control means for displaying measured data.

11. An automatic continuous analysis apparatus having an analytical implement automatic supplying device as claimed in claim 10, including an analytical implement hopper having a bottom section with an analytical implement groove, wherein at least one wall surfaces other than one which is parallel with the analytical implement groove and one opposite to it is parallel with a moving direction of the analytical implement groove, and the bottom surface is inclined so that it is lower at one the parallel inside wall surfaces than the other.

12. An automatic continuous analysis device as claimed in claim 11 which is provided on the outside of the wall where the analytical implement groove passes, with an inversion device for inverting an analytical implement fitted in the analytical implement groove reversely in top-and-bottom direction.

13. An automatic continuous analysis device as claimed in claim 11 which is provided on the outside of the wall where the analytical implement groove passes, with a removing device for removing a non-conforming analytical implement by pressing it in opposite direction to the wall.