Method of producing liposome
First Claim
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1. A method of producing liposomes with increased drug trap ratio, which comprises (1) providing a dispersion containing a drug and liposomes prepared from a phospholipid, (2) adding an organic solvent having a boiling point not higher than 100°
- C. to the dispersion to cause gel formation, and then (3) removing said organic solvent by evaporation to reconstitute liposomes.
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Abstract
Liposomes with an increased drug trap can be prepared by adding a readily volatile organic solvent to a drug-containing liquid with liposomes dispersed therein to cause gel formation and then removing said organic solvent by evaporation.
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Citations
13 Claims
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1. A method of producing liposomes with increased drug trap ratio, which comprises (1) providing a dispersion containing a drug and liposomes prepared from a phospholipid, (2) adding an organic solvent having a boiling point not higher than 100°
- C. to the dispersion to cause gel formation, and then (3) removing said organic solvent by evaporation to reconstitute liposomes.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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