In-vivo stimulation, collection, and modification of peritoneal macrophage
First Claim
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1. An apparatus for collection of macrophage from the peritoneal cavity of a vertebrate including,container means consisting essentially of membrane means, completely enclosing therein an interior volume, for excluding tissue growth into said interior volume and for permitting permeation of macrophage through said membrane means into said interior volume, andcell supporting means filling at least a portion of said interior volume.
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Abstract
The instant invention pertains to improvements in processes and apparatus for stimulating, collecting, and optionally modifying, macrophages from the peritoneal cavity of a vertebrate.
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Citations
24 Claims
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1. An apparatus for collection of macrophage from the peritoneal cavity of a vertebrate including,
container means consisting essentially of membrane means, completely enclosing therein an interior volume, for excluding tissue growth into said interior volume and for permitting permeation of macrophage through said membrane means into said interior volume, and cell supporting means filling at least a portion of said interior volume.
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2. An apparatus for collection of macrophage from the peritoneal cavity of a vertebrate including:
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container means including;
a housing of a material which is impermeable to tissue ingrowth and defining at least one aperture;
membrane means, sealing fluid tight said at least one aperture whereby said housing and membrane means cooperate to completely enclose therein an interior volume, for excluding tissue growth through said at least one aperture into said interior volume and for permitting permeation of macrophage through said membrane means into said interior volume, whereby said housing and said membrane means cooperate to exclude tissue growth into said interior volume; andcell supporting means filling at least a portion of said interior volume. - View Dependent Claims (3, 18, 19)
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23. A process comprising,
implanting within the peritoneal cavity of a vertebrate a macrophage collector means, collecting macrophage within said macrophage collector means, removing macrophage from said macrophage collector, means externally of said vertebrate, antigen priming the removed macrophage to arm the removed macrophage against at least one antigen, and introducing the antigen primed macrophage into a vertebrate.
Specification