Devices for neural signal transmission

• US 4,878,913 A
• Filed: 09/04/1987
• Issued: 11/07/1989
• Est. Priority Date: 09/04/1987
• Status: Expired due to Fees

• Current Assignee: Brown University
• Original Assignee: Pfizer Hospital Products Group, Inc. (Pfizer Inc.)
• Inventors: Aebischer, Patrick, Valentini, Robert F., Galletti, Pierre M.
• Primary Examiner(s): Cannon, Alan W.
• Application Number:
  US07/093,371
• Time in Patent Office: 795 Days
• Field of Search: 623/66, 623/12, 623/24, 623/25, 128/1 R, 128/334 R, 128/642, 439/70, 437/93, 437/188, 204/286, 204/28 R, 204/290 R
• US Class Current: 623/23.64
• CPC Class Codes: A61F 2/72 Bioelectric control, e.g. myoelectric

Abstract

Devices and methods for transmitting neural signals from a proximal stump of a transected nerve to a prosthetic apparatus are disclosed employing microelectrodes, preferably conductive fiber networks, capable of sensing electrical signals from a nerve and transmitting such signals to a prosthetic apparatus; and a semipermeable guidance channel disposed about the microelectrodes. The channels include an opening adapted to receive the proximal stump of a transected nerve, such that the channel promotes the growth of the stump and the formation of an electrical connection between the transected nerve and the microelectrode.

Claims

1. A device for transmitting neural signals from a proximal stump of a transected nerve to a prosthetic apparatus, said transmission device comprising:

a microelectrode capable of sensing electrical signals from a nerve and transmitting said signals to said prosthetic apparatus; and

a guidance channel disposed about said microelectrode, comprising a tubular, semipermeable membrane and having a capped distal end and a proximal end which defines an opening adapted to receive a proximal stump of a transected nerve, whereby said channel promotes the growth of said stump, such that an electrical connection between said transected nerve and said microelectrode can be obtained.

2. The transmission device of claim 1 wherein said microelectrode comprises a conductive fiber network.

3. The transmission device of claim 2 wherein the conductive fiber network further includes an array of parallel carbon fibers which traverse the nerve guidance channel.

4. The transmission device of claim 3 wherein the carbon fibers range from about 10 microns to about 50 microns in diameter.

5. The transmission device of claim 3 wherein the spacing between carbon fibers ranges from about 50 microns to about 500 microns.

6. The transmission device of claim 2 wherein the conductive fibers are platinum fibers.

7. The transmission device of claim 2 wherein said conductive fiber network is mounted upon a yoke disposed about the channel.

8. The transmission device of claim 7 wherein the yoke comprises an insulating biocompatible material.

9. The transmission device of claim 7 wherein the yoke comprises a silicon material.

10. The transmission device of claim 1 wherein said tubular membrane further includes a lumen ranging from about 0.5 millimeters to about 2.0 centimeters in diameter.

11. The transmission device of claim 1 wherein said semipermeable channel has an upper limit on permeability ranging from about 5,000 to about 200,000 daltons in molecular weight.

12. The transmission device of claim 1 wherein said semipermeable channel has an upper limit on permeability ranging from about 50,000 to about 150,000 daltons in molecular weight.

13. The transmission device of claim 1 wherein the device further includes at least one neurotropic material seeded within the channel.

14. The transmission device of claim 13 wherein the neurotropic material is selected from the group consisting of NGF, MDGF, PDGF, EDGF, FGF, laminin, fibronectin, and alpha 1-acid glycoprotein.

15. The transmission device of claim 1 wherein the channel further comprises an acrylic copolymer material.

16. The transmission device of claim 1 wherein the guidance channel further comprises a porous outer membrane surface which permits capillary ingrowth, and a smooth inner membrane surface which permits regeneration of the nerve therethrough.