Method and composition for preventing the adsorption of a medicine

• US 4,879,272 A
• Filed: 10/04/1985
• Issued: 11/07/1989
• Est. Priority Date: 10/09/1984
• Status: Expired due to Fees

• Current Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Original Assignee: Chugai Seiyaku Kabushiki Kaisha (Roche Holding AG)
• Inventors: Kawaguchi, Tsutomu, Shimoda, Naoto
• Primary Examiner(s): Griffin, Ronald W.
• Assistant Examiner(s): Stone, Jacqueline M.
• Application Number:
  US06/784,640
• Time in Patent Office: 1,495 Days
• Field of Search: 424/99, 424/101, 514/8, 514/970, 514/814, 514/774, 514/776, 530/380, 530/395, 436/8
• US Class Current: 514/7.7
• CPC Class Codes: A61K 38/1816 Erythropoietin [EPO]
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 47/44 Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin synthetic glycerides, e.g. medium-chain triglycerides, A61K47/14
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing

Abstract

A method of preventing erythropoietin in an aqueous solution from being adsorbed on the inner surface of the wall of a container by incorporating in the aqueous solution one or more additives, and an erythropoietin composition so formulated as to avoid the adsorption of erythropoietin onto the inner surface of the wall of a container are disclosed.

The additives which are useful in this invention include human serum albumin, bovine serum albumin, lecithin, dextrans, ethylene oxide-propylene oxide copolymers, hydroxypropyl cellulose, methylcellulose, polyoxyethylene hydrogenated castor oils, polyethylene glycols and the like. A

Claims

1. A method of preventing erythropoietin in an aqueous solution from being adsorbed on the inner surface of the wall of a container by incorporating in the aqueous solution one or more additives selected from the group consisting of human serum albumin and bovine serum albumin.

2. A method according to claim 1 wherein said one or more additives are incorporated in amounts of 0.001-1% (w/v) of the erythropoietin-containing aqueous solution.

3. An erythropoietin-containing, pharmaceutically-acceptable composition wherein human serum albumin is mixed with erythropoietin either during the preparation of said composition or just before administration thereof.

4. An erythropoietin-containing composition according to claim 3 wherein said bovine serum albumin is incorporated in amounts of 0.001-1% (W/V) of an aqueous solution in which said composition is dissolved.