Bone ingrowth chamber

• US 4,880,006 A
• Filed: 11/23/1987
• Issued: 11/14/1989
• Est. Priority Date: 11/21/1986
• Status: Expired due to Term

• Current Assignee: Nobelpharma AB
• Original Assignee: Nobelpharma AB
• Inventors: Aspenberg, Per, Albrektsson, Tomas
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): Lacyk, John P.
• Application Number:
  US07/124,149
• Time in Patent Office: 722 Days
• Field of Search: 128/630, 623/16, 623/66, 73/508
• US Class Current: 600/300
• CPC Class Codes: A61B 10/00 Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis vaccination prophylaxis, vaccination therapy A61B17/20; Sex determination; Ovulation-period determination menstruation tables G06C3/00; Throat striking implements
• CPC Class Codes: A61B 10/025 for taking bone, bone marrow or cartilage samples
• CPC Class Codes: A61B 17/68 Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin bone staples A61B17/0642
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/468 Testing instruments for artificial joints for testing non-implantable prostheses A61F2/76
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/30235 tubular, e.g. sleeves
• CPC Class Codes: A61F 2002/30433 using additional screws, bolts, dowels, rivets or washers e.g. connecting screws
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2220/0041 using additional screws, bolts, dowels or rivets, e.g. connecting screws
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 2310/00023 Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00407 Coating made of titanium or of Ti-based alloys
• CPC Class Codes: A61M 2039/025 through bones or teeth, e.g. through the skull
• CPC Class Codes: A61M 2039/0267 comprising sensors or electrical contacts
• CPC Class Codes: A61M 2039/0276 for introducing or removing fluids into or out of the body
• CPC Class Codes: A61M 2039/0294 having a specific shape matching the shape of a tool to be inserted therein, e.g. for easy introduction, for sealing purposes, guide
• CPC Class Codes: A61M 2210/02 Bones
• CPC Class Codes: A61M 2230/005 : Parameter used as control input for the apparatus
• CPC Class Codes: A61M 39/0247 : Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053
• CPC Class Codes: Y10S 623/914 : Bone

Abstract

An apparatus for studying the bone formation or bone ingrowth in an implant, in response to locally administered test substances of different types, is made of bio-compatible material, preferably pure titanium, and is implanted in living bone tissue, primarily for animal experiment activities. The apparatus has an outer portion with a central recess in which an inner portion is removably inserted. The two portions form, in the assembled state, a bone tissue ingrowth channel which is exposed when the inner portion is removed, whereby allowing examination of tissue which has grown into the channel. The inner portion includes a reservoir for the test substance whose bone formation promoting properties are to be tested. The reservoir is connected to the bone tissue ingrowth channel through a capillary aperture, so-called diffusion capillary, for supply of the test substance without simultaneous liquid flow.

Claims

1. An apparatus of a bio-compatible material for implantation in a living bone tissue and for studying bone tissue formation growth in an implant in response to a locally administered test substance, said apparatus comprising;

an outer portion with a central recess extending therethrough and a removable inner portion insertable in said central recess;

means provided in at least a bottom wall of said outer portion cooperating with a bottom wall of said inner portion to form a bone tissue ingrowth channel when said inner portion is fully inserted into said central recess, said channel being exposable for access thereto when said inner portion is removed upwardly, thereby allowing examination of said bone tissue ingrowth in said channel; and

a reservoir provided in said inner portion, said reservoir including means for fluid communication with said bone tissue ingrowth channel for supplying said test substance to said bone tissue ingrowth channel.

2. An apparatus according to claim 1, wherein said means forming said bone tissue ingrowth channel includes a first groove formed in the bottom wall of said outer portion and a second groove corresponding to said first groove and aligned therewith to form said channel when said inner portion is fully inserted into said central recess.

3. The apparatus as claimed in claim 1, wherein said inner and outer portions are made of pure titanium.

4. The apparatus as claimed in claim 1, wherein said inner and outer portions have at least those surfaces which come into direct contact with the bone tissue, coated with pure titanium.

5. The apparatus as claimed in claim 2, wherein said inner and outer portions have at least those surfaces which come into direct contact with the bone tissue, coated with pure titanium.

6. The apparatus as claimed in claim 1, wherein said reservoir includes a cavity provided in said inner portion and extending therethrough to communicate with said bone tissue ingrowth channel and wherein said means for fluid communication includes a capillary aperture for the supply of the test substance without simultaneous liquid flow.

7. The apparatus as claimed in claim 2, wherein said reservoir includes a cavity provided in said inner portion and extending therethrough to communicate with said bone tissue ingrowth channel and wherein said means for fluid communication includes a capillary aperture for the supply of the test substance without simultaneous liquid flow.

8. The apparatus as claimed in claim 6, wherein said reservoir includes an elongate, diagonally disposed cavity of substantially the same orientation as said bone tissue ingrowth channel and two holes extending through said outer and inner portions for receiving locking screws for fixed interlocking of said inner and outer portions.

9. The apparatus as claimed in claim 8, wherein said two holes extend through said inner portion on opposite sides of said elongate cavity.

10. The apparatus as claimed in claim 9, wherein said reservoir is upwardly covered by a cover plate which is locked to the upper end surface of said inner portion by locking screws received in said holes.

11. The apparatus as claimed in claim 10, wherein said cover plate is provided with two openings at the location above said liquid reservoir for receiving hoses for supply and removal (drainage), respectively, of the test substance.

12. The apparatus as claimed in claim 11, wherein said reservoir is connected to a subcutaneous, osmotically acting minipump for continuous supply of the test substance to said bone tissue ingrowth channel during a predetermined period of time.