Continuous method of tableting

• US 4,880,585 A
• Filed: 12/22/1988
• Issued: 11/14/1989
• Est. Priority Date: 04/11/1986
• Status: Expired due to Term

• Current Assignee: BASF AG (BASF SE)
• Original Assignee: BASF AG (BASF SE)
• Inventors: Klimesch, Roger G., Goertz, Hans-Helmut, Farwerck, Karl-Peter, Schlemmer, Lothar, Bleckmann, Gerhard
• Primary Examiner(s): Thurlow, Jeffery
• Assistant Examiner(s): Tentoni, Leo B.
• Application Number:
  US07/289,407
• Time in Patent Office: 327 Days
• Field of Search: 264/141, 264/151, 264/167, 264/210.2, 264/211.12, 264/280, 264/282, 264/297.5, 264/320, 264/325, 264/331 A, 425/112, 425/115, 425/116, 425/121, 425/122, 425/327, 425/363, 425/408, 424/486
• US Class Current: 264/141
• CPC Class Codes: A61J 2200/20 Extrusion means, e.g. for producing pharmaceutical forms
• CPC Class Codes: A61J 3/10 into the form of compressed tablets tablet presses B30B11/00
• CPC Class Codes: A61K 9/2095 Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: B29B 9/06 in the form of filamentary material, e.g. combined with extrusion
• CPC Class Codes: B29K 2503/00 Use of resin-bonded materials as filler
• CPC Class Codes: B30B 11/16 using pocketed rollers, e.g. two co-operating pocketed rollers
• CPC Class Codes: B30B 15/308 in a continuous manner, e.g. for roller presses, screw extrusion presses

Abstract

Extrudable pharmaceutical mixtures are tableted by a continuous method in which the mixture is extruded and the still deformable extrudate is pressed between two rollers which are driven in opposite directions and possess depressions opposite one another in the roller shell, the form of these depressions determining the tablet shape.

Claims

1. A continuous method for producing separate tablets of an extrudable pharmaceutical mixture which comprises:

mixing a pharmaceutically active compound and an N-vinylpyrrolid-2-one (NVP) polymer containing 30 to 100% by weight NVP in an extruder to form a melt, said polymer having a K value of from 10 to 100, said mixture having a glass transition point of less than 180°

C.;

extruding the melt and pressing the still deformable extrudate between the surfaces of two rollers driven in opposite directions, the surfaces of said rollers having opposed depressions, whereby, separate tablets having the shape of the opposed depressions are formed.

2. The method of claim 1, wherein an active compound-containing melt of an N-vinylpyrrolid-2-one (NVP) polymer is extruded and pressed, the NVP polymer being prepared either in an organic solvent or using an organic peroxide in water.

3. The method of claim 1, wherein the K value of the polymer is from 12 to 35 and the mixture has a softening or melting point of from 60°

to 130°

C. and a glass transition point of less then 130°

C.