Water-soluble phosphazene polymers having pharmacological applications

• US 4,880,622 A
• Filed: 05/20/1986
• Issued: 11/14/1989
• Est. Priority Date: 05/20/1986
• Status: Expired due to Fees

• Current Assignee: Pennsylvania Research Corporation
• Original Assignee: Research Corporation Technologies
• Inventors: Kwon, Sukky, Allcock, Harry R., Austin, Paul E.
• Primary Examiner(s): Schofer, Joseph L.
• Assistant Examiner(s): Kulkosky, Peter F.
• Application Number:
  US06/865,504
• Time in Patent Office: 1,274 Days
• Field of Search: 424/78, 424/468
• US Class Current: 514/772.3
• CPC Class Codes: A01N 25/10 Macromolecular compounds
• CPC Class Codes: A61K 9/2031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
• CPC Class Codes: C08G 79/025 Polyphosphazenes

Abstract

Novel poly(organophosphazene) polymers are used for the controlled release of pharmaceuticals, pesticides, herbicides, plant growth regulators and fertilizers. These polymers also act as foam control agents.

Claims

1. A controlled release article of manufacture comprising a member selected from the group consisting of pharmaceuticals, pesticides, herbicides, plant growth regulators, and fertilizers in a physical admixture with a matrix of a polymer of the formula:

space="preserve" listing-type="equation">[NPR(R.sub.2)]n

wherein (a) R is selected from the group consisting of lower alkoxy ethers or polyethers, imines, polyimines, sulfides, polysulfides, esters and polyesters, and (b) n is from about 10 to about 20,000.

2. The article of claim 1 wherein R is a polyether.

3. The article of manufacture of claim 1 where R is:

space="preserve" listing-type="equation">Alk--OCH.sub.2 CH.sub.2).sub.x O--

x is from 1 to about 100

and Alk is lower alkyl.

4. The article of manufacture of claim 1 where R is:

##STR4## x is from 1 to about 100 Alk is lower alkyl.

5. The article of manufacture of claim 1 where R is:

##STR5## the sum of y and z is from 2 to about 100 Alk is lower alkyl.

6. The article of manufacture of any of claims 1 through 5 where said polymer is cross-linked.