Application of tetrathiafulvalenes in bioelectrochemical processes
First Claim
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1. A bioelectrochemical system comprising:
- a biological system comprising a redox system which requires electron transfer for its operation, wherein said redox system comprises an enzyme;
an electrode; and
a mediator for transferring electrons between said electrode and the enzyme of said redox system for operation of said redox system, characterized in that said mediator is tetrathiafulvalene, and is not complexed with an electron acceptor molecule.
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Abstract
Bioelectrochemical processes use tetrathiafulvalenes (TTF) as a mediator of electron transfer between biological systems and electrodes. Typically it finds use in bioelectrochemical assays, e.g. involving glucose oxidase mediated oxidation of glucose. The TTF may be immobilized on the electrode surface, as may one or more enzymes involved in the process.
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Citations
14 Claims
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1. A bioelectrochemical system comprising:
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a biological system comprising a redox system which requires electron transfer for its operation, wherein said redox system comprises an enzyme; an electrode; and a mediator for transferring electrons between said electrode and the enzyme of said redox system for operation of said redox system, characterized in that said mediator is tetrathiafulvalene, and is not complexed with an electron acceptor molecule. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An assay procedure for assaying a substance, comprising:
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causing the substance to participate in a redox system provided by a biological system, said redox system requiring electron transfer for its operation, wherein said redox system comprises an enzyme; providing an electrode; employing said electrode in an electrochemical cell including said redox system; providing tetrathiafulvalene as a mediator for transferring electrons between said electrode and the enzyme of said redox system for operation of said redox system; and deriving assay data from the electrode'"'"'s response. - View Dependent Claims (10)
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- 11. An electrode for use in a bioelectrochemical system, said electrode consisting essentially of a conductive surface onto which a tetrathiafulvalene and an oxidoreductase enzyme are deposited, wherein said tetrathiafulvalene is not complexed with an electron acceptor.
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14. An electrode for use in a bioelectrochemical system, said electrode comprising a graphite conductive surface onto which a coating consisting essentially of tetrathiafulvalene is provided, wherein said tetrathiafulvalene is not complexed with an electron acceptor.
Specification