Confectionery delivery system for laxatives, vitamins and antacids

• US 4,882,152 A
• Filed: 10/14/1988
• Issued: 11/21/1989
• Est. Priority Date: 12/20/1985
• Status: Expired due to Fees

• Current Assignee: James J. Shaw, Robert K. Yang, Shan-Shan Sheu, Shri C. Sharma
• Original Assignee: James J. Shaw, Robert K. Yang, Shan-Shan Sheu, Shri C. Sharma
• Inventors: Yang, Robert K., Sheu, Shan-Shan, Shaw, James J., Sharma, Shri C.
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US07/258,285
• Time in Patent Office: 403 Days
• Field of Search: 424/440, 424/441
• US Class Current: 424/440
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/1617 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/5015 Organic compounds, e.g. fats, sugars

Abstract

A chewable delivery system for actives comprising:

(a) an active pre-coatd with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having chain lengths of about 4 carbons or less, glycerides having a melting point of 100° C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof; and p1 (b) a confectionery matrix comprising a binder system comprising gelatin and a humectant material selected from the group consisting of glycerin and its lower alkyl (C_2-7) ester derivatives; a sweetener; and about 1% to about 30% by weight water.

Claims

1. A chewable confectionery delivery system for laxatives, vitamins and antacids comprising:

(a) a laxative, vitamin and antacid pre-coated with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having chain lengths of about 4 carbons or less, glycerides having a melting point of 100°

C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof; and

(b) a confectionery matrix comprising a binder system comprising from about 0.1% to about 5% by weight gelatin and a humectant material selected from the group consisting of glycerin and its lower alkyl (C_2-7) ester derivatives, a sweetener; and

about 1% to about 30% by weight water, all weights are in percent of the final delivery system.

2. The delivery system of claim 1 wherein the material used for the pre-coating of the active is present in amounts of about 1 to about 10% by weight of the total delivery system.

3. The delivery system of claim 1 wherein the ratio of coating to achive is about 1:

3 to about 1;

8 parts by weight.

4. The delivery system of claim 1 wherein the material used for the pre-coating of the active is selected from the group consisting of polyoxyethylene, polyoxypropylene, polyoxybutylene, copolymers of these and mixtures thereof.

5. The delivery system of claim 1 wherein the polyalkyleneglycol is selected from the group consisting of polyethyleneglycol, polypropyleneglycol, polybutyleneglycol and mixtures thereof.

6. The delivery system of claim 1 wherein the binder system comprises about 0.1 to about 5.0% gelatin and about 0.1 to about 25% of the humectant material.

7. The delivery system of claim 6 wherein the humectant is selected from the group consisting of glycerine, triacetin, tributyrin and mixtures thereof.

8. The delivery system of claim 1 wherein there is additionally incorporated a nonionic hydrocolloid gum.

9. The delivery system of claim 8 wherein the gum is selected from the group consisting of guar gum, locust bean gum, and mixtures thereof.

10. The delivery system of claim 1 wherein there is additionally included a material selected from the group consisting of pectin, sweeteners, flavorings, colorings, humectants, fillers, emulsifiers, thickeners, and mixtures thereof.

11. The delivery system of claim 1 wherein the precoated laxative, vitamin and antacid is present in a pharmaceutically effective amount.

12. The delivery system of claim 1 wherein the precoated laxative, vitamin and antacid comprises about 15 to about 30% by weight of the final product.

13. A method of preparing a confectionery delivery system for laxatives, vitamins and antacids comprising:

(a) pre-coating the laxative, vitamin and antacid with at least one material selected from the group consisting of lecithin, polyoxyalkylenes having a chain length of about 4 carbons or less, glycerides having a melting point of 100°

C. or less, polyalkyleneglycols having a molecular weight of 3,700 or less, synthetic and natural waxes and mixtures thereof, wherein the coating does not interfere with the function or release of the active; and

(b) preparing a confectionery matrix comprising the steps of (i) forming a solution of gelatin and a humectant selected from the group consisting of glycerin and its lower alkyl (C_2-7) ester derivatives;

a sweetener; and

about 1% to about 30% by weight water; and

(c) admixing mixtures from (a) and (b) together; and

(d) forming the resultant delivery system into shapes.