Artificial skin

• US 4,882,162 A
• Filed: 09/08/1988
• Issued: 11/21/1989
• Est. Priority Date: 06/26/1987
• Status: Expired due to Term

• Current Assignee: Dow Corning Kabushiki Kaisha, Gunze Kabushiki Kaisha
• Original Assignee: Dow Corning Kabushiki Kaisha
• Inventors: Kawashima, Hiroyuki, Urabe, Yosuke, Ikada, Yoshito, Gen, Shokyu, Ohi, Shigeo
• Primary Examiner(s): Page, Thurman K.
• Application Number:
  US07/242,085
• Time in Patent Office: 439 Days
• Field of Search: 424/444, 424/424, 424/424, 623/15
• US Class Current: 424/444
• CPC Class Codes: A61F 2/105 Skin implants, e.g. artificial skin
• CPC Class Codes: A61F 2013/00157 for burns or skin transplants A61F2013/00187 takes precedence; not adhering to the wound A61F2013/00217
• CPC Class Codes: A61F 2013/00221 biodegradable, non-irritating
• CPC Class Codes: A61F 2013/00259 thin film
• CPC Class Codes: A61F 2013/00263 vapour permeability >500 g/m2/24h
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 27/60 Materials for use in artificial skin
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

An artificial skin or bandage is formed from an elastomeric layer which is surfaced by a fibrous wound contacting layer which is first formed into a fabric and subsequently degraded by heat hydrolysis or other degradative treatment into a form which could no longer be formed into a fabric but which forms an ideal bioabsorbable wound contact surface in which damage to the newly formed, fragile epidermus is minimized.

Claims

1. Artificial skin characteristically consisting of a polymer support film and a woven or knitted fabric formed of fibrous material fixed on said polymer support film, wherein the fabric is prepared from bioabsorbable substance which has an initial strength when formed into a fabric of 90 to 168 grams per fiber and the strength of said fibrous material has been reduced to approximately 30 to 67 grams per fiber of degradative treatment.

2. Artificial skin as described in claim 1 wherein the fibrous material is a knit or a weave having the density of 5 to 200 grams per square meter, preferably 5 to 50 grams per square meter, with most preference of 10 to 25 grams per square meter.

3. Artificial skin as described in claim 2 wherein the fibrous material is prepared from a bioabsorbable substance selected from polyglycolic acid, polylactic acid and copolymers thereof.

4. Artificial skin as described in claim 1 wherein the fibrous material is prepared from polyglycolic acid.

5. Artificial skin as described in claim 3 wherein the polymer support film is prepared from silicone elastomer.

6. Artificial skin as described in claim 1 wherein the degradative treatment is carried out in hot water or in atmosphere of super heated steam in an autoclave.

7. Artificial skin as described in claim 6 wherein the degradative treatment is carried out in hot water at temperature of 80 to 100 degrees Centigrade.

8. Artificial skin as described in claim 6 wherein the degradative treatment is carried out in atmosphere of high pressure water vapor at 100 to 140 degrees Centigrade.

9. Artificial skin as described in claim 6 wherein the fibrous material has an initial tensile strength of at least 50 grams per fiber and the degradative treatment is carried out to the extent that the strength of the fibrous material is degraded to less than 60 percent of the initial strength thereof.

10. Artificial skin as described in claim 6 wherein the degradative treatment is carried out after the fibrous material is fixed on the polymer support film.

11. Artificial skin as described in claim 1 wherein the fibrous material is treated with biologically acceptable-material as herein defined.