Light sensitive liposomes
First Claim
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1. A light sensitive liposome comprising:
- a lipid membrane, said lipid membrane encapsulating a fluid, said lipid membrane including a light sensitive lipid in an amount from about 50 wt.% to about 100 wt.% of the lipid membrane and having a polar head region and a nonpolar tail region, said light sensitive lipid including one retinoyl group or two retinoyl groups covalently bonded in the nonpolar tail region of said light sensitive lipid, said light sensitive lipid having an absorptive of light at a predetermined wavelength between about 300 nm to about 400 nm, said light sensitive lipid providing release of said fluid from said lipid membrane in response to an effective amount of irradiation at said predetermined wavelength.
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Abstract
Light sensitive liposomes are provided which release their contents on demand in response to irradiation with an appropriate wavelength of light. Substantially all the liposome contents can be released within about 60 seconds.
Preferred embodiments of the light sensitive liposomes include lipids having at least one retinoyl group and being a structural component of the lipid membrane.
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15 Claims
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1. A light sensitive liposome comprising:
a lipid membrane, said lipid membrane encapsulating a fluid, said lipid membrane including a light sensitive lipid in an amount from about 50 wt.% to about 100 wt.% of the lipid membrane and having a polar head region and a nonpolar tail region, said light sensitive lipid including one retinoyl group or two retinoyl groups covalently bonded in the nonpolar tail region of said light sensitive lipid, said light sensitive lipid having an absorptive of light at a predetermined wavelength between about 300 nm to about 400 nm, said light sensitive lipid providing release of said fluid from said lipid membrane in response to an effective amount of irradiation at said predetermined wavelength. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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