Bioerodible articles useful as implants and prostheses having predictable degradation rates

• US 4,886,870 A
• Filed: 02/15/1985
• Issued: 12/12/1989
• Est. Priority Date: 05/21/1984
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Langer, Robert S., Leong, Kam W., D'Amore, Patricia
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Moore, M. L.
• Application Number:
  US06/702,168
• Time in Patent Office: 1,761 Days
• Field of Search: 528/271, 528/206, 623/1, 524/17, 524/21, 524/599, 424/19, 424/78
• US Class Current: 528/271
• CPC Class Codes: A61L 17/10 containing macromolecular materials
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08G 67/04 Polyanhydrides
• CPC Class Codes: C08L 73/02 Polyanhydrides

Abstract

A novel series of articles useful as implants and prostheses and methods for their preparation and use are provided which utilize polyanhydride polymeric matrices as a general class of materials. These articles are biocompatible, non-inflammatory and degrade predictably into non-toxic residues after introduction in-vivo. The articles may be formed in any desired dimensions and configuration and may take specific shape as vascular or skin grafts, as biodegradable sutures or as orthopedic appliances such as bone plates and the like.

Claims

1. An article useful for implantation or otherwise placed in or on the body, comprising a biocompatible, bioerodible, hydrophobic polyanhydride composition of the formula ##STR8## wherein R is an organic group and n is at least 2, said polyanhydride being purified and characterized by biocompatibility that results in minimal tissue irritation when implanted in vasculated tissue and degrading at predictable, constant rates by hydrolysis into non-toxic residues after introduction in vivo.

2. The article as recited in claim 1 wherein said R group is a hydrocarbon comprising from 2-16 carbon atoms.

3. The article as recited in claim 1 wherein said R group is ##STR9##

4. The article as recited in claim 1 where in the R group is ##STR10## wherein x is not less than 2 and not more than 16.

5. The article as recited in claim 1 wherein said R group is ##STR11## wherein x is at least 1.

6. The article as recited in claim 1 wherein said R group is ##STR12## wherein x is at least 1 and y is at least 1.

7. The article as recited in claim 1 wherein said R group is selected from the group consisting of ##STR13## wherein R'"'"' and R" are organic groups.