Apparatus for performing dual energy medical imaging

• US 4,887,604 A
• Filed: 05/16/1988
• Issued: 12/19/1989
• Est. Priority Date: 05/16/1988
• Status: Expired due to Term

• Current Assignee: Joseph A. Mangano, Linda Buchanan
• Original Assignee: Science Research Laboratory, Inc.
• Inventors: Shefer, Ruth, Petrasso, Richard, Klinkowstein, Robert E.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Pfaffle, Krista M.
• Application Number:
  US07/194,190
• Time in Patent Office: 582 Days
• Field of Search: 378/51, 378/62, 378/99, 378/143, 378/144, 378/156, 128/653, 128/654, 128/659
• US Class Current: 600/431
• CPC Class Codes: A61B 6/4035 the source being combined with a filter or grating
• CPC Class Codes: A61B 6/4092 for producing synchrotron radiation
• CPC Class Codes: A61B 6/482 involving multiple energy imaging
• CPC Class Codes: G21K 1/10 Scattering devices; Absorbing devices; Ionising radiation filters
• CPC Class Codes: H05G 1/26 Measuring, controlling or protecting measuring X-ray radiation G01T
• CPC Class Codes: H05G 1/60 Circuit arrangements for obtaining a series of X-ray photographs or for X-ray cinematography

Abstract

An energy substraction medical imaging system which is used for imaging a body part impregnated with a radio-opaque dye such as iodine is provided. The system includes an electron beam target having a target surface which, when excited by a high-energy electron beam, generates radiation having strong K.sub.α at energy levels slightly above and slightly below the K-edge energy level of the dye. The target surface is preferably formed of a compound containing lanthanum, such as lanthanum oxide. The target may also be formed of a compound containing a material having a K.sub.α line at an energy level slightly above the dye K-edge and a material with K.sub.α line slightly below the dye K-edge or with separate sections containing such materials which are alternately excited. The target is excited by a high-energy electron beam from a suitable source, the electron beam having sufficient energy to provide a high photon yield at the K.sub.α line energy levels and sufficient power to produce the required photon fluences at such energy lines for the medical imaging application. One of the K.sub.α lines in the radiation output from the excited target is selectively filtered and the output from the filter, both with the K.sub.α line filter and with the line unfiltered, are passed through the body part being imaged to an x-ray detector. The output from the detector in response to the filtered and unfiltered outputs is processed to obtain an image of the body part. Continuum radiation from the target is reduced by filtering the continuum radiation at frequencies above the below the K.sub.α line energy levels of the target compound, by viewing the radiation from the target in the backward direction to the beam, and by having the thickness of the target equal to a fraction of the electron range in the target compound material.

Claims

1. A dual energy medical imaging system for imaging a body part through which a radio-opaque dye is flowing, said dye having a predetermined K-edge energy level, comprising:

an electron beam target having a target surface which, when excited by a high-energy electron beam, generates a radiation output having strong K.sub.α

lines at energy levels slightly above and slightly below the K-edge energy level of the dye;

means for appling an electron beam to excite said target, said beam having sufficient energy to provide a high photon yield at the K.sub.α

line energy levels and sufficient power to obtain the photon fluence required for a medical imaging application;

filter means for selectively either filtering or passing unfiltered at least one of the K.sub.α

lines in the radiation output from the excited target surface;

an x-ray detector;

means for passing the output of said filter means with both said at least one K.sub.α

line filtered and said at least one K.sub.α

line unfiltered through the body part being imaged to said x-ray detector; and

means for processing the energy received at the detector in response to the filtered and unfiltered outputs from the filtering means to obtain an image of the body part.

2. A system as claimed in claim 1 wherein said radio-opaque dye contains iodine having a K-edge at 33.16 KeV;

and

wherein said target surface is formed of a compound containing lanthanum.

3. A system as claimed in claim 2 wherein said compound is lanthanum oxide.

4. A system as claimed in claim 1 wherein said radio-opaque dye contains iodine having a K-edge at 33.16 KeV;

and

wherein said target surface is formed of a compound containing barium and cerium.

5. A system as claimed in claim 1 wherein a selected part of said target surface is covered with a first compound generating a strong K.sub.α

line at an energy level slightly above the K-edge energy level of the dye and another selected part of the target surface is covered with a second compound generating a strong K.sub.α

line at an energy level slightly below said K-edge energy level; and

further comprising

means for rotating the target surface to alternatively apply the electron beam to said first and second compounds.

6. A system as claimed in claim 5 wherein said first compound contains cerium and wherein said second compound contains barium.

7. A system as claimed in claim 1 wherein the energy of said electron beam is greater than 80 KeV.

8. A system as claimed in claim 1 wherein the energy of said electron beam is greater than 500 KeV.

9. A system as claimed in claim 8 wherein said electron beam has an energy of approximately 1 MeV.

10. A system as claimed in claim 9 wherein said electron beam has an average current over a 5 mS period of 0.5 to 1 amp.

11. A system as claimed in claim 1 wherein said electron beam applying means includes a radio frequency accelerating resonator.

12. A system as claimed in claim 2 further including means for reducing continuum radiation from the target.

13. A system as claimed in claim 12 wherein said means for reducing includes means for filtering continuum radiation from the target at frequencies above and below the K.sub.α

line energy levels.

14. A system as claimed in claim 12 wherein said means for reducing includes means for viewing the radiation from the target in the backward direction.

15. A system as claimed in claim 12 wherein said means for reducing includes the thickness of the compound used for said target being thinner than R, where R equals one electron range in the compound material.

16. A system as claimed in claim 15 wherein the target thickness is 0.1 to 0.3R.

17. A system as claimed in claim 1 including means for protecting the target from overheating.

18. A system as claimed in claim 17 wherein said means for protecting includes means for rotating the target.

19. A system as claimed in claim 17 wherein said means for protecting includes forming said target surface thin enough so that electrons of the electron beam pass through the surface before they sustain large energy loss, and a backing means for said target surface, said backing means having good thermal properties.

20. A system as claimed in claim 1 wherein said means for filtering filters the higher energy K.sub.α

line, resulting in an unfiltered image having energy I₁ =I_L +I_H ; and

a filtered image having an energy I₂ =I_L ;

where I_L and I_H are the energy received at the lower energy K.sub.α

line and the energy received at the higher energy K.sub.α

line respectively; and

wherein said means for processing determines the difference image by use of the equation D=wln (I_L /I_LO)-1n (I_H /I_HO)

where;

I_LO and I_HO are energy incident at the low energy K.sub.α

line and the high energy K.sub.α

line respectively;

w is the ratio of the high energy to the low energy tissue attenuation coefficient.

21. A method for performing coronary angiography on a subject comprising the steps of:

placing an iodine dye at an appropriate point in the bloodstream of the subject, the iodine having a predetermined K-edge energy level;

exciting a target formed of a compound containing lanthanum with a high energy electron beam, the lanthanum generating strong K.sub.α

lines in response to the exciting electron beam at an energy level slightly above the iodine K-edge level and a level slightly below the iodine K-edge level;

viewing radiation from said excited target in the backward direction;

selectively filtering the emitted radiation to remove energy emitted at a high K.sub.α

line of the lanthanum target radiation;

successively passing the filtered and unfiltered radiation from the target through a part of the subject'"'"'s body to be imaged to a detector; and

processing the detected radiation to determine the intensity in a difference image which represents the iodinated portion of the imaged body part;

whereby an image of the part of the subject s body containing the iodine dye may be obtained.