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Method and apparatus for detecting low concentrations of (bio) chemical components present in a test medium using surface plasmon resonance

  • US 4,889,427 A
  • Filed: 04/11/1988
  • Issued: 12/26/1989
  • Est. Priority Date: 04/10/1987
  • Status: Expired due to Fees
First Claim
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1. In a method for detecting low concentrations of at least one chemical component present in a test medium in a test cell, the test cell having a metal layer as sub wall with an external glass prism, using the surface plasmon resonance effect in which a light ray polarized in the plane of incidence is coupled in via the prism and, after attenuated total reflection, is coupled out and the intensity thereof is measured, the incidence angle position of the resonance curve being determined under the influence of change caused in the dielectric constant of the test medium near the metal layer by the chemical component, the improvement comprising providing the metal layer as an array of metal layer strips, each strip being provided with a different selector from a selector array of one type, and simultaneously determining concentrations or concentration changes of one or more components in the test medium through one or more differential measurements caused by a preferential association between each component and such a selector.

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