Apparatus for performing determinations of immune reactants in biological fluids
First Claim
1. Apparatus for performing in vitro determinations of immune reactants, such as antigens and antibodies, in biological fluids of humans or animals, comprising:
- a plurality of test units, each test unit including an elongated rod having proximal and distal ends and a tip secured at said distal end;
wherein said tips have different respective immune reactant coatings, each coating being of the type which reacts in a known manner with a respective corresponding immune reactive counterpart in biological fluid;
visible coding means for distinguishing, by a visible identifier, each of said test units from all of the others of said test units; and
holder means for supporting said plurality of test units in spaced parallel side-by-side relation;
wherein said tips include a first multi-faceted section having a transverse configuration that expands as a function of length displacement away from proximal end, and a second multi-faceted section having a transverse configuration that contracts as a function of length displacement away from said proximal end, said second section being disposed further than said first section from said proximal end.
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Abstract
Apparatus for performing determinations of immune reactants (e.g., antigens, antibodies) in bodily fluids includes multiple test units having respective elongated rods with transversely-expanded tips at their distal ends. The tips are each coated with respective immune reactants (e.g., allergens of the type which react in a known manner with respective allergen-specific or allergen-binding antibodies in human serum. The test units are color-coded. By correlating the color code to a chart, the specific immune reactant (e.g., allergen) coating can be easily identified. The supporting strip for the test unit has through-holes which frictionally engage the proximal ends of the test unit rods with a spacing that permits all of the supported test units to be simultaneously inserted into an assembly of reaction containers arranged in a linear array. The through-hole spacing in the strip permits alternate test units to be simultaneously placed in an array of test tubes that are transversely larger than the reaction containers and supported in a linear array in a test tube rack. The tip of each test unit may take the form of two frusto-conical joined by a short cylindrical section extending longitudinally beween their larger ends. The frusto-conical sections may be multi-faceted to minimize scraping of the allergen coating from the tip during insertion and removal of the test units into the reaction containers/test tubes.
78 Citations
3 Claims
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1. Apparatus for performing in vitro determinations of immune reactants, such as antigens and antibodies, in biological fluids of humans or animals, comprising:
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a plurality of test units, each test unit including an elongated rod having proximal and distal ends and a tip secured at said distal end; wherein said tips have different respective immune reactant coatings, each coating being of the type which reacts in a known manner with a respective corresponding immune reactive counterpart in biological fluid; visible coding means for distinguishing, by a visible identifier, each of said test units from all of the others of said test units; and holder means for supporting said plurality of test units in spaced parallel side-by-side relation; wherein said tips include a first multi-faceted section having a transverse configuration that expands as a function of length displacement away from proximal end, and a second multi-faceted section having a transverse configuration that contracts as a function of length displacement away from said proximal end, said second section being disposed further than said first section from said proximal end.
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2. Apparatus for performing in vitro semi-quantitative determinations of allergen-specific antibodies in human serum comprising:
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a plurality of test units, each test unit including an elongated rod having proximal and distal ends and a tip secured to said distal end; wherein said tips have different respective allergen coatings, each allergen coating being of the type that reacts in a known manner with a respective allergen binding antibody in human serum; holder means for supporting said plurality of test units in spaced parallel side-by-side relation; wherein said tips include a first multi-faceted section having a transverse configuration that expands as a function of length away from proximal end, and a second multi-faceted section having a transverse configuration that contracts as a function of length away from said proximal end, said second section being disposed further than said first section from said proximal end.
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3. Apparatus for performing in vitro determinations of immune reactants, such as antigens and antibodies, in biological fluids of humans or animals, comprising:
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a plurality of test units, each test unit including an elongated rod having proximal and distal ends and a tip secured at said distal end; wherein said tips have different respective immune reactant coatings, each coating being of the type which reacts in a known matter with a respective corresponding immune reactive counterpart in biological fluid; visible coding means for distinguishing, by a visible identifier, each of said test units from all of the others of said test units; holder means for supporting said plurality of test units in spaced parallel side-by-side relation; decoding means, separate and apart from said test units, for indicating the nature of the immune reactant coating on each of said tips by correlating each immune reactant coating to a respective one of said visible identifiers; wherein said visible identifier is the color of the test units; wherein said holder means comprises an elongated strip having a plurality of spaced through-holes defined therein, each through-hole being sized to receive and engage the proximal end of a respective rod; wherein said through-holes are disposed in a straight linear array with equal spacing between each pair of adjacent throughholes; an assembly of plural reaction containers secured together and arranged side-by-side in a straight linear array, the centers of adjacent containers being equally spaced by the same spacing provided between adjacent through-holes; wherein each reaction container has an opening that is larger in size than the largest transverse dimension of said tips to permit simultaneous insertion of said plurality of test units, suspended by said strip, into respective containers of said array; and further comprising a test tube rack having at least one linear array of openings adapted to support a respective array of test tubes, the centers of adjacent openings in said rack being spaced by twice the spacing provided between adjacent through-holes in said strip.
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Specification