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Intra-pocket drug delivery devices for treatment of periodontal diseases

  • US 4,892,736 A
  • Filed: 06/03/1988
  • Issued: 01/09/1990
  • Est. Priority Date: 10/07/1983
  • Status: Expired due to Term
First Claim
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1. A therapeutic agent delivery and maintenance system suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket and maintaining it there, comprising:

  • (a) therapeutic material selected from the group of therapeutic agents consisting of antibacterials, antibiotics, antiinflammatory agents, immune-suppressive agents, immune-stimulatory agents, dentinal desensitizers, odor masking agents, immune reagents, anesthetics, nutritional agents, antioxidants, lipopolysaccharide complexing agents, and peroxides;

    (b) biocompatible polymeric material selected from the group of polymers consisting of collagen, cellulosic polymers, glycolic acid polymers, methacrylate polymers, ethylene vinyl acetate copolymers, ethylene vinyl alcohol copolymers, and polycaprolactone;

    said polymeric material containing said therapeutic material impregnated therein and being permeable to said therapeutic material;

    said polymeric material being in the form of a fiber having a diameter of 0.1 to 1 mm and being sufficiently formable and flexible to conform to the site to be treated; and

    (c) means, separate from the therapeutic agent-containing polymeric material, for maintaining said therapeutic agent-containing polymeric material within said periodontal pocket in contact with the site to be treated, said maintaining means also serving to limit diffusion of said therapeutic agent from said pocket.

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