Intra-pocket drug delivery devices for treatment of periodontal diseases
First Claim
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1. A therapeutic agent delivery and maintenance system suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket and maintaining it there, comprising:
- (a) therapeutic material selected from the group of therapeutic agents consisting of antibacterials, antibiotics, antiinflammatory agents, immune-suppressive agents, immune-stimulatory agents, dentinal desensitizers, odor masking agents, immune reagents, anesthetics, nutritional agents, antioxidants, lipopolysaccharide complexing agents, and peroxides;
(b) biocompatible polymeric material selected from the group of polymers consisting of collagen, cellulosic polymers, glycolic acid polymers, methacrylate polymers, ethylene vinyl acetate copolymers, ethylene vinyl alcohol copolymers, and polycaprolactone;
said polymeric material containing said therapeutic material impregnated therein and being permeable to said therapeutic material;
said polymeric material being in the form of a fiber having a diameter of 0.1 to 1 mm and being sufficiently formable and flexible to conform to the site to be treated; and
(c) means, separate from the therapeutic agent-containing polymeric material, for maintaining said therapeutic agent-containing polymeric material within said periodontal pocket in contact with the site to be treated, said maintaining means also serving to limit diffusion of said therapeutic agent from said pocket.
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Abstract
Therapeutic agent delivery devices and methods for using them in treatment of dental disease are disclosed. In the treatment of periodontal disease, a therapeutic agent such as tetracycline mixed in a polymeric matrix such as ethylene vinyl acetate copolymer is packed into the area to be treated and kept in place for a suitable time, during which the therapeutic agent diffuses out of the polymeric matrix, providing continuous therapy for the treatment site.
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Citations
9 Claims
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1. A therapeutic agent delivery and maintenance system suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket and maintaining it there, comprising:
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(a) therapeutic material selected from the group of therapeutic agents consisting of antibacterials, antibiotics, antiinflammatory agents, immune-suppressive agents, immune-stimulatory agents, dentinal desensitizers, odor masking agents, immune reagents, anesthetics, nutritional agents, antioxidants, lipopolysaccharide complexing agents, and peroxides; (b) biocompatible polymeric material selected from the group of polymers consisting of collagen, cellulosic polymers, glycolic acid polymers, methacrylate polymers, ethylene vinyl acetate copolymers, ethylene vinyl alcohol copolymers, and polycaprolactone;
said polymeric material containing said therapeutic material impregnated therein and being permeable to said therapeutic material;
said polymeric material being in the form of a fiber having a diameter of 0.1 to 1 mm and being sufficiently formable and flexible to conform to the site to be treated; and(c) means, separate from the therapeutic agent-containing polymeric material, for maintaining said therapeutic agent-containing polymeric material within said periodontal pocket in contact with the site to be treated, said maintaining means also serving to limit diffusion of said therapeutic agent from said pocket. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A therapeutic agent delivery system suitable for continuously delivering a pharmacologically-effective level of therapeutic agent to the site of a periodontal infection within a periodontal pocket and maintaining it there, comprising:
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a fiber of an ethylene vinyl acetate copolymer, said fiber having a diameter of 0.1 to lmm and containing tetracycline or a pharmaceutically-acceptable acid addition salt thereof impregnated therein at a level of 10 to 50% by weight; and means, separate from said tetracycline-containing fiber, for maintaining said tetracycline-containing fiber within said periodontal pocket in contact with the site to be treated, said maintaining means also serving to limit diffusion of said therapeutic agent from said pocket.
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Specification