Therapeutic agent delivery system

• US 4,894,231 A
• Filed: 07/28/1987
• Issued: 01/16/1990
• Est. Priority Date: 07/28/1987
• Status: Expired due to Fees

• Current Assignee: Biomeasure, Inc. (Ipsen Sa)
• Original Assignee: Biomeasure, Inc. (Ipsen Sa)
• Inventors: Moreau, Jacques-Pierre, Kitchell, Judith P.
• Primary Examiner(s): Page, Thurman K.
• Application Number:
  US07/078,534
• Time in Patent Office: 903 Days
• Field of Search: 424/484, 424/426, 424/422, 424/502, 427/2, 427/3
• US Class Current: 424/426
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/5031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Abstract

A therapeutic agent delivery system that includes a biodegradable polymer and a therapeutic agent, the delivery system being coated with a barrier substance that decreases the quantity of the agent released from the system, compared to the quantity of the agent released from a system not coated with the substance, in the forty-eight hours subsequent to the parenteral injection or implantation of the system into a living person or animal.

Claims

1. A therapeutic agent delivery system comprising a biodegradable polymer and a therapeutic agent, said delivery system being coated with a barrier substance that decreases the quantity of said agent released from said system, compared with the quantity of said agent released from a said system not coated with said barrier substance, in the forty-eight hours subsequent to the parenteral injection or implantation of said system into a living person or animal, said barrier substance being selected from the group consisting of a paraffin, beeswax, or a silicone oil and being adapted to dissipate from said delivery system within a short time period after said injection or implantation.

2. The coated therapeutic agent delivery system of claim 1 wherein said barrier substance is a silicone oil.

3. The coated therapeutic agent delivery system of claim 2 wherein said silicone oil has a viscosity of between 10² centipoise and 10⁴ centipoise.

4. The coated therapeutic agent delivery system of claim 2 wherein said silicone oil has a viscosity of between 500 centipoise and 2000 centipoise.

8. The coated delivery system of claim 1 wherein said short period is 5 days or less.

9. The coated delivery system of claim 8 wherein said short period is 2 days or less.

5. A method of providing a coated therapeutic agent delivery system comprising

coating a therapeutic agent delivery system comprising a biodegradable polymer and therapeutic agent with a barrier substance that decreases the quantity of said agent released from said system, compared with the quantity of said agent released from a said system not coated with said substance, in the forty-eight hours subsequent to the parental injection or implantation of said system into a living person or animal, said barrier substance being selected from the group consisting of a paraffin, beeswax, or a silicone oil;

and

treating said delivery system to remove some but not all of said barrier substance.

6. The method of claim 5 wherein said barrier substance is a silicone oil.

7. The method of claim 5 wherein said treating comprises washing said delivery system with a solvent.