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Novel drug delivery system for antiarrhythmics

  • US 4,894,234 A
  • Filed: 07/26/1988
  • Issued: 01/16/1990
  • Est. Priority Date: 10/05/1984
  • Status: Expired due to Term
First Claim
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1. A dry particulate drug delivery system designed to be chewed or swallowed whole comprising:

  • (A) an antiarrhythmic in an amount of about 1%, to about 75%; and

    (B) a hydrophobic matrix comprising(i) about 0.5% to about 20% by weight of an emulsifier; and

    (ii) about 61% to about 95% by weight of an edible material having a melting point in the range of about 25°

    C. to about 100°

    C. selected from the group consisting of fatty acids having an iodine value of about 1 to about 10, (b) natural waxes, (c) synthetic waxes and (d) mixtures thereof; and

    (iii) at least one glyceride, wherein the antiarrhythmic and hydrophobic matrix form an agglomerate, and(C) a coat effective to delay hydration until ingested comprising about 200% to about 400% by weight of the agglomerate an edible material having a melting point in the range of about 25°

    C. to about 100°

    C. selected from the group consisting of (a) fatty acids having an iodine value of about 1 to about 10, (b) natural waxes, (c) synthetic waxes and (d) mixtures thereof;

    wherein the coat forms a protective barrier effective to prevent unpleasant taste perception for the antiarrhythmic agglomerate.

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