2-(5-phenyl-2-furanyl)imidazoles useful as cardiotonic agents

• US 4,895,867 A
• Filed: 01/19/1988
• Issued: 01/23/1990
• Est. Priority Date: 06/26/1986
• Status: Expired due to Term

• Current Assignee: Norwich Eaton Pharmaceuticals, Inc. (The Procter & Gamble Company)
• Original Assignee: Norwich Eaton Pharmaceuticals, Inc. (The Procter & Gamble Company)
• Inventors: Huang, Chau-Ting, White, Ralph L. Jr., Pelosi, Stanford S. Jr.
• Primary Examiner(s): Lee, Mary C.
• Assistant Examiner(s): NORTHINGTON DAVIS, ZINNA
• Application Number:
  US07/145,073
• Time in Patent Office: 735 Days
• Field of Search: 548/336, 514/397
• US Class Current: 514/397
• CPC Class Codes: C07D 405/04 directly linked by a ring-member-to-ring-member bond

Abstract

The present invention involves certain 2-(5-phenyl-2-furanyl)-imidazoles, pharmaceutical compositions containing such compounds, and methods for enhancing the contractile force of cardiac muscle of a mammal which comprises systemically administering such compounds to a mammal.

Claims

1. A method for enhancing the contractile force of cardiac muscle of a mammal which comprises systemically administering to said mammal an effective amount of a composition comprising a compound conforming to the following chemical structure:

##STR5## wherein R¹ is mono- or di- substituents selected from the group consisting of hydrogen, halo, nitro, trifluoromethyl, straight and branched chain C₁ -C₅ alkyl, acetyl, propionyl, methoxy and ethoxy; and

R² is mono- or di- substituents selected from the group consisting of hydrogen, methyl and ethyl;

or a pharmaceutically acceptable salt or hydrate thereof.

2. The method of claim 1 wherein R² is hydrogen.

3. The method of claim 1 wherein R² is mono- or di- substituents selected from the group consisting of methyl and ethyl.

4. The method of claim 1 wherein R¹ comprises a substituent selected from the group consisting of halo and trifluoromethyl.

5. The method of claim 4 wherein R² is mono- or di- substituents selected from the group consisting of methyl and ethyl.

6. The method of claim 1 wherein R¹ is selected from the group consisting of hydrogen, 2-fluoro, 2-chloro, 4-chloro, 2-bromo, 4-bromo, 4iodo, 3-trifluoromethyl, 4-trifluoromethyl, 4-methyl, 4-isopropyl, 4-methoxy, 2,4-dichloro, 3,4-dichloro, 2,4-dibromo, 2-bromo-4-methyl, 2-methyl-4-bromo, 3-trifluoromethyl-4-bromo, 3-methoxy-4-bromo, and 2-nitro-4-methoxy.

7. The method of claim 6 wherein R² is hydrogen.