Continuous cardiac output by impedance measurements in the heart

• US 4,898,176 A
• Filed: 06/22/1988
• Issued: 02/06/1990
• Est. Priority Date: 06/22/1988
• Status: Expired due to Term

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Petre, John H.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): GETZOW, SCOTT M
• Application Number:
  US07/210,095
• Time in Patent Office: 594 Days
• Field of Search: 128/695, 128/642, 128/713, 128/692, 128/673, 361/390
• US Class Current: 600/374
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter

Abstract

A diagnostic catheter for use in measuring cardiac output in the right ventricular chamber of a heart includes a catheter body having an outer periphery and a distal section terminating in a distal end and a proximal section terminating in a proximal end. A plurality of spaced electrodes are secured to the body outer periphery along the body distal section. A plurality of electrical leads extend in the catheter body from a respective one of the electrodes to the proximal end of the catheter body. An elongated rigid member is provided for stiffening a portion of the catheter body. One end of the rigid member is located adjacent a proximal most one of a plurality of electrodes. The rigid member so locates the plurality of electrodes as to space them away from endocardial tissue. The catheter is used with a cardiac output monitoring system. Signals from the catheter are acquired by a signal conditioning and catheter control unit and, are thereafter fed to a microcomputer. The catheter and the system are used in a method for determining the instantaneous volume of blood in a heart chamber.

Claims

1. A diagnostic catheter for use in measuring cardiac output in the right ventricular chamber comprising:

(a) an elongated, multi-lumen, flexible member having a distal end and a proximal end, a first lumen extending the entire length of said member and terminating in a distal port, a second port extending through the side wall of said member at a location immediately proximate of said distal end of said flexible member and a second lumen extending from said proximal end of said member to said second port;

(b) an expandable sleeve surrounding said member and spanning said second port, said sleeve inflatable by a fluid introduced into the proximal end of said second lumen;

(c) a plurality of ring electrodes secured to the outer surface of said member at predetermined axial spacing including a distal ring electrode located a first predetermined distance proximal of said distal end of said flexible member, a proximal ring electrode located a second predetermined distance greater than said first predetermined distance from said distal end of said flexible member and a further plurality of intermediate ring electrodes disposed between said distal ring electrode and said proximal ring electrode;

(d) a plurality of electrical conductors extending longitudinally through a third lumen in said flexible member from said proximal end of said flexible member and individually connected to separate ones of said plurality of ring electrodes; and

,

(e) a first stiffening member disposed in a fourth lumen in said flexible member and extending from a third predetermined distance to a fourth predetermined distance proximal of said distal end of said flexible member, said third and fourth distances being greater than said second predetermined distance.

2. The diagnostic catheter as in claim 1 and further including a fifth lumen extending from said proximal end of said flexible member and terminating in a third port formed through the side wall of said flexible member and located within said first predetermined distance;

and a thermistor element exposed to heat conduction through said third port and having conductor means extending therefrom through said fifth lumen to the proximal end of said flexible member.

3. The diagnostic catheter as in claim 2 wherein said third port containing said thermistor includes a plastic seal covering said thermistor, said plastic having a thermal conductivity property allowing said thermistor to detect a small temperature change rapidly.

4. The diagnostic catheter as in claim 1 and further including a fourth port extending through the side wall of said flexible member and communicating with said fourth lumen at a location proximal of said stiffening member.

5. The diagnostic catheter as in claim 1 and further including a multi-terminal electrical connector connected to said plurality of electrical conductors.

6. The diagnostic catheter as in claim 1 and further including valve means connected to the proximal end of said second lumen of said flexible member.

7. A catheter for measuring cardiac output, comprising:

a catheter body having an outer periphery and a distal section terminating in a distal end and a proximal section terminating in a proximal end;

a plurality of spaced electrodes secured to said body outer periphery along said body distal section;

a plurality of electrical leads, each one extending in said catheter body from a respective one of said electrodes to said proximal end of said catheter body; and

an elongated rigid means for stiffening a portion of said catheter body, a distal end of said rigid means being located proximally of a proximal-most of one said plurality of electrodes, said rigid means being located proximally of said plurality of electrodes in order to allow them to be spaced away from endocardial tissue when said catheter body is correctly located in a heart.

8. The catheter of claim 7 further comprising a first lumen extending longitudinally through said catheter body from said body proximal end to a distal-most one of said plurality of electrodes, wherein said plurality of electrical leads are located in said first lumen.

9. The catheter of claim 8 further comprising a second lumen which extends from a proximal end of said catheter body to a port located at approximately 15 cm from said distal end of said catheter body.

10. The catheter of claim 9 further comprising:

a balloon sleeve located adjacent a distal tip of said catheter body;

a third lumen communicating said balloon with said proximal end of said catheter body; and

,

a fourth lumen extending from said catheter body proximal end to a port located on said catheter body distal end.

11. The catheter of claim 10 further comprising a fifth lumen extending from said body proximal end and terminating in a port formed through side wall of said body and located at a predetermined distance from a proximalmost one of said plurality of electrodes.

12. The catheter of claim 7 further comprising:

a thermistor sensor secured to said catheter body and spaced distally from a distal-most one of said plurality of electrodes; and

,

an electrical lead extending in said catheter body from said thermistor to said proximal end of said catheter body.

13. The catheter of claim 7 wherein said plurality of electrodes comprises ten electrodes which are spaced apart from each other by approximately 0.8 to 1.0 cm and wherein a distal-most one of said plurality of electrodes is located at approximately 9 cm from said distal end of said catheter body.

14. The catheter of claim 7 wherein said stiffening means comprises an elongated stylet disposed in a lumen of the catheter, said stylet extending proximally from adjacent a proximal-most one of said plurality of electrodes.

15. The catheter of claim 7 further comprising a pair of drive electrodes, wherein a distal electrode and a proximal electrode of said plurality of electrodes serve as said pair of drive electrodes and wherein said stiffening means so locates said distal electrode and said proximal electrode as to be positioned adjacent a pulmonic valve and a tricuspid valve of the heart, respectively.

16. The catheter of claim 7 further comprising a terminal means secured to said catheter body proximal end for receiving a free end of each of said plurality of electrical leads.

17. A catheter for measuring cardiac output, comprising:

an elongated flexible multi-lumen catheter body having an outer periphery and a distal section terminating in a distal end and a proximal section terminating in a proximal end;

a balloon attached to said distal end of said body;

a first lumen extending the entire length of said catheter body and terminating in a first port which communicates with an interior surface of said balloon;

a plurality of spaced electrodes secured to said body outer periphery along said body distal section proximal of said balloon;

a second lumen extending from a distal most one of said plurality of spaced electrodes to said proximal end of said body;

a plurality of electrical leads, each one extending through said second lumen from a respective one of said electrodes to said proximal end of said catheter body; and

,

a means for taking blood pressure measurements in a right ventricle of a heart when the catheter is fully inserted in the heart, said means comprising a third lumen which extends longitudinally in said catheter body from said proximal end to a second port intermediate said plurality of spaced electrodes, wherein said second port is adapted to take blood pressure measurements as the port passes through a tricuspid valve and becomes stationary in the right ventricle of the heart.

18. The catheter of claim 17 further comprising:

a fourth lumen which extends longitudinally in said catheter body from said proximal end to a third port which is located proximally of said plurality of spaced electrodes; and

,

a stiffening member disposed in said fourth lumen distally of said third port.

19. The catheter of claim 17 further comprising a thermistor sensor secured to said catheter body and spaced proximally from said balloon.

20. The catheter of claim 17 wherein ten ring electrodes are provided which are spaced apart from each other by approximately 0.8 to 1.0 cm and wherein a distal-most one of said plurality of electrodes is located at approximately 9 cm from said distal end of said catheter body.

21. The catheter of claim 17 further comprising a multi-terminal electrical connector connected to said plurality of electrical leads.