Means for the application of transdermally absorbable active substances
First Claim
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1. A device for application of a heated transdermally absorbable active substance to skin, comprising at least one replaceable carrier impregnated with a transdermally absorbable active substance, and a laminate support housing the carrier comprising:
- (a) a first closed-cell polyethylene foam layer having a thickness of 2 to 6 mm, said first foam layer including a foil-facing area and a laminate-contacting area defined on a first surface, and an opposite surface,(b) a second closed-cell polyethylene foam layer having a thickness of 2 to 5 mm, said second foam layer including a laminate-contacting surface bonded to said laminate-contacting area of the first foam layer and an opposite, skin-contacting surface, wherein at least one portion of said second foam layer has been removed to define pink-shaped side walls housing the carrier, and(c) a flexible heat-conductive metal foil, said metal foil including a first surface facing said foil-contacting surface of the first foam layer and an opposite surface facing said carrier.
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Abstract
A device for the application of heated transdermally absorbable active substances has a carrier impregnated with a transdermally absorbable active substance and a support. The support is a laminate made up of one or more polymeric layers and optionally includes a heat conductive element. A preferred mode of carrier attachment involves the use of a magnetic connector.
66 Citations
22 Claims
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1. A device for application of a heated transdermally absorbable active substance to skin, comprising at least one replaceable carrier impregnated with a transdermally absorbable active substance, and a laminate support housing the carrier comprising:
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(a) a first closed-cell polyethylene foam layer having a thickness of 2 to 6 mm, said first foam layer including a foil-facing area and a laminate-contacting area defined on a first surface, and an opposite surface, (b) a second closed-cell polyethylene foam layer having a thickness of 2 to 5 mm, said second foam layer including a laminate-contacting surface bonded to said laminate-contacting area of the first foam layer and an opposite, skin-contacting surface, wherein at least one portion of said second foam layer has been removed to define pink-shaped side walls housing the carrier, and (c) a flexible heat-conductive metal foil, said metal foil including a first surface facing said foil-contacting surface of the first foam layer and an opposite surface facing said carrier. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A device for application of a heated transdermally absorbable active substance to skin, comprising at least one replaceable carrier impregnated with a transdermally absorbable active substance, and a laminate support housing the carrier comprising:
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(a) a first closed-cell polyethylene foam layer having a thickness of 1 to 5 mm, said first foam layer including a foil-bonding surface and an opposite surface, (b) a flexible heat-conductive metal foil including a surface bonded to said foil-bonding surface of the first foam layer, and an opposite surface, (c) a second closed-cell polyethylene foam layer having a thickness of 1 to 4 mm, said second foam layer including a surface bonded to said opposite surface of the metal foil, and an opposite surface, and (d) a third closed-cell polyethylene foam layer having a thickness of 1 to 4 mm, said third foam layer including a laminate-contacting surface bonded to said opposite surface of the second foam layer and an opposite, skin-contacting surface, wherein at least one portion of said third foam layer has been removed to define side walls surrounding an area housing the carrier, the size of the housing area being equal to or slightly larger than the surface area of the carrier. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A device for application of a heated transdermally absorbable active substance to skin, comprising at least one replaceable carrier impregnated with a transdermally absorbable active substance, and a laminate support housing the carrier comprising:
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(a) a first closed-cell polyethylene foam layer having a thickness of 2 to 5 mm, said first foam layer including a foil-bonding surface and an opposite surface, (b) a flexible heat-conductive metal foil including a surface bonded to said foil-bonding surface of the first foam layer, and an opposite surface, (c) a second closed-cell polyethylene foam layer having a thickness of 2 to 5 mm, said second foam layer including a laminate-contacting surface bonded to said opposite surface of the foil and an opposite, skin-contacting surface, wherein at least one portion of said second foam layer has been removed to define side walls surrounding an area housing the carrier, the size of the housing area being equal to or slightly larger than the surface area of the carrier. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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Specification