Polymer composite for controlled release or membrane formation

• US 4,898,734 A
• Filed: 02/29/1988
• Issued: 02/06/1990
• Est. Priority Date: 02/29/1988
• Status: Expired due to Term

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Edelman, Elazar, Langer, Robert S., Mathiowitz, Edith, Warshawsky, Abraham
• Primary Examiner(s): Page, Thurman K.
• Application Number:
  US07/162,161
• Time in Patent Office: 708 Days
• Field of Search: 424/426, 424/422, 424/486, 424/484, 424/469, 424/487
• US Class Current: 424/426
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A61K 9/1641 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/2077 Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
• CPC Class Codes: A61K 9/2081 with microcapsules or coated microparticles according to A61K9/50
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: B01J 13/025 Applications of microcapsules not provided for in other subclasses

Abstract

The present invention is a method to produce novel composites based on microcapsules or microspheres embedded in contiuous polymeric matrices. Both non-bioerodible and erodible polymers can be used. Material can be incorporated into the microcapsules or microspheres for subsequent release. In one embodiment of the present invention, spheres are homogeneously dispersed in a polymer matrix and then forced to release their contents by exposure to temperature, light or ultrasound. Alternatively, polymers which degrade as a function of time or hydrolysis can be used for controlled releases. The polymer composites have completely different properties from either a continuous polymer matrix or microcapsules or microspheres and are therefore useful for a wide variety of applications. When carbon tetrachloride is the incorporated material, the film is useful as a flame retarding device. When foaming agents are used, especially UV or heat sensitive materials, gas can be evolved inside each capsul

The Government has rights in this invention pursuant to Grant Number 5-R01-GM26698 awarded by the Department of Health and Human Services.

Claims

1. A method for making a composite polymeric device comprising:

providing a compound to be released,

incorporating the compound to be released into polymer spheres,

mixing the polymer spheres into a liquified polymer matrix, and

solidifying the polymer matrix.

2. The method of claim 1, wherein the polymer spheres are embedded within the liquified polymer matrix by

dissolving the polymer matrix in an organic solvent in which the polymer spheres are not soluble,

suspending the polymer spheres in the liquified polymer matrix solution, and

removing the solvent.

3. The method of claim 2 wherein the liquified polymer matrix is dissolved in an amount of organic solvent which produces a viscous solution.

4. The method of claim 2 wherein the solvent is highly volatile and is rapidly removed by evaporation before the microspheres settle.

5. The method of claim 1, wherein the compound to be released is selected from the group consisting of solvents, lubricants, flame retardants, preservatives, antioxidants, bioactive compounds, insecticides, herbicides, fertilizers, and foaming agents.

6. The method of claim 1, wherein the polymers are selected from the group consisting of polystyrene, polyethylene acetate, polyethylenevinyl acetate, polyurethane, polyamide, polyacrylamide, polymethacrylate, polylactic acid, polyglycolic acid, polyanhydrides, polyorthoester, and derivatives thereof.

7. The method of claim 1, wherein the compound to be released is a drug, at least one polymers is biodegradable, and the drug is released by erosion of the erodible polymer.

12. The polymeric device of claim 3 wherein said polymer matrix can be applied directly to the skin of a patient.

14. The method of claim 1, wherein the liquified polymer matrix is melted.

15. The method of claim 1, wherein the polymer matrix is liquified by heating and solidified by cooling.

16. The method of claim 1, wherein the polymer matrix is solidified by polymerizing monomers of the polymer.

8. A method for forming a porous membrane comprising

providing polymer spheres,

mixing the polymer spheres within a liquified polymeric matrix, and

rupturing the polymer spheres to leave pores in the solidified polymeric matrix.

9. The method of claim 8 further comprising encapsulating a gas forming compound within the polymer spheres and releasing the gas when the polymer spheres are ruptured into the continuous polymeric matrix to produce a porous polymeric structure.

10. The method of claim 9 further comprising using the porous structure at a site for cell growth.

11. The method of claim 10 further comprising using the porous structure as a membrane of varying porosity.

13. The polymeric device of claim 9 wherein said polymer spheres are ruptured within said polymeric matrix by exposure to ultrasound, light, radiation, or temperature,

said polymer spheres contain a bioactive compound, and

the bioactive compound diffuses out of said polymeric matrix following rupture of said polymer spheres.