Dispensing catheter and method

• US 4,900,303 A
• Filed: 03/25/1986
• Issued: 02/13/1990
• Est. Priority Date: 03/10/1978
• Status: Expired due to Term

• Current Assignee: Jerome H. Lemelson
• Original Assignee: Jerome H. Lemelson
• Inventors: Lemelson, Jerome H.
• Primary Examiner(s): Truluck, Dalton L.
• Application Number:
  US07/843,990
• Time in Patent Office: 1,421 Days
• Field of Search: 128/334 R, 604/57, 604/59, 604/60, 604/54, 604/285-287, 604/890, 604/11
• US Class Current: 604/514
• CPC Class Codes: A61B 1/00165 with light-conductive means, e.g. fibre optics A61B1/07 takes precedence
• CPC Class Codes: A61B 2017/22077 with a part piercing the tissue A61B2017/22044 takes precedence
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/02154 by optical transmission
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61M 2025/0002 with a pressure sensor at the distal end
• CPC Class Codes: A61M 2025/009 the needle having a bent tip, i.e. the needle distal tip is angled in relation to the longitudinal axis of the catheter
• CPC Class Codes: A61M 2025/0096 being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0069 Tip not integral with tube
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 31/007 Injectors for solid bodies, e.g. suppositories
• CPC Class Codes: A61M 37/0069 Devices for implanting pellets, e.g. markers or solid medicaments for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027
• CPC Class Codes: A61N 5/1002 Intraluminal radiation therapy
• CPC Class Codes: A61N 5/1014 Intracavitary radiation therapy

Abstract

Medical catheters and methods are provided for dispensing and implanting materials and devices within the bodies of living beings. In one form, an implantable device or material is disposed within the operating head of a catheter which is caused to move through a body duct to a select location therein which location is detected either by externally scanning the body duct with radiation or ultrasonic energy or by viewing an image of the body duct adjacent the head of the catheter by means of a fiber optical viewing system including a fiber optic cable extending along the catheter. When properly located, a mechanical, electro-mechanical and/or fluidically operated mechanism in the head of the catheter is operated causing a select quantity of an implantable material or an implant to be forced from the head and caused to engage a select portion of the wall of the body duct and attach thereto to retain such implant or material in engagement therewith. In a particular form, attachment is effected by means of a biodegradeable adhesive which sets in situ per se or between the implant of implantable material and the tissue of the wall of the body duct. Thereafter the catheter is retracted and either completely removed from the wall of the body duct or is disposed at a second location and the procedure repeated with respect to a second implant or second quantity of material to be attached to the wall of the body duct.

Claims

1. A method for treating a living being with a medical material delivered to the body of said living being by means of a catheter, said method comprising:

(a) disposing a select quantity of an encapsulated medical material along with a biodegradeable adhesive in the operating head of a catheter, which catheter includes means for controllably moving said encapsulated medical material and said adhesive from said operating head,

(b) manipulating said catheter into and through a body duct of the body of said living being to dispose said operating head at a select location in the body of said living being,

(c) operating said catheter after said operating head has reached said select location to move said encapsulated medical material and said adhesive a distance from said operating head and to dispose said medical material adhesively bonded by said adhesive against a select portion of the surface of said body duct aligned with said operating head,

(d) removing said catheter from said body duct while leaving said encapsulated medical material adhered to said select portion of said body duct,

(e) retaining said medical material bonded against the wall of said body duct while allowing said medical material to slowing release from encapsulation and flow to the body of said living being and effect medical treatment within the body of said living being.

2. A method in accordance with claim 1 wherein said medical material is contained within a biodegradeable capsule to which capsule biodegreadeable adhesive is applied and used to effect the adhesive bonding of said medical material to said select portion of said body duct.

3. A method in accordance with claim 1 wherein said medical material is disposed within a plurality of biodegradeable capsules which are retained together as a medical dose and bonded as such to said select portion of said body duct with said biodegradeable adhesive and wherein said biodegradeable capsules are caused to release their contents to the body as they become exposed to and degrade under the effect of body fluid within said body duct.

4. A method in accordance with claim 1 wherein said medical material is adhesively retained within the head of said catheter until it is moved therefrom and adhesively bonded to said select portion of said body duct.

5. A method in accordance with claim 1 wherein the operating head of said catheter has a passageway containing said medical material and an opening at the end of said passageway, said method including urging movement of said medical material and said adhesive through said passageway and out said opening to dispose said medical material against a select portion of the surface of said body duct to adhesively bond same thereto.

6. A method in accordance with claim 1 wherein the operating head of said catheter has a passageway containing said medical material and said biodegradeable adhesive, which passageway extends lateral to the longitudinal axis of said operating head and wherein said operating head has an opening therein at the end of said passageway, said method including urging movement of said medical material through said passageway and out said opening to dispose said medical material against a select portion of the surface of said body duct to adhesively bond same thereto.

7. A method in accordance with claim 1 which includes allowing said adhesive to degrade after said medical material has been released from encapsulation to the body of said living being.

8. A method in accordance with claim 1 which steps (a) to (c) are repeated a number of times to adhesively secure select quantities of said encapsulated medical material against different portions of the wall of said body duct.

9. A method for delivering a medical material of the body of a living being comprising:

(a) forming a select quantity of medical treatment material,

(b) disposing a select amount of said medical material in a small container formed with a wall portion thereof made at least partly of a bio-degradeable material which degrades upon contact with body fluid in a manner to release said medical treatment material from said container,

(c) disposing said small container with a quantity of adhesive secured thereto in the operating head of a dispensing catheter and inserting said catheter into a body duct of a living being,

(d) working said catheter through said body duct to dispose said operating head in alignment with select body tissue,

(e) expelling said small container from said operating head to cause it to contact select tissue within the body and to cause said adhesive to bond said container to the tissue it contacts,

(f) removing said catheter from the body duct,

(g) allowing body fluid to react on said biodegradeable material of said container while it is adhesively bonded to said tissue in a manner to cause said medical material to become released from said container and to be dispensed therefrom into the body of said living being.

10. A method for delivering a medical material to the body of a living being comprising:

(a) forming a select quantity of medical treatment material,

(b) encapsulating said medical material in a plurality of microcapsules formed of bio-degradeable material which degrades upon contact with body fluid in a manner to release said medical material from said microcapsules,

(c) forming a drug dose defined by a select amount of said microcapsules with an adhesive,

(d) disposing said drug dose in the operating head of a dispensing catheter,

(e) inserting said catheter into the body of a living being and disposing the operating head thereof in alignment with select tissue of said living being,

(f) expelling a select amount of said mixture of microcapsules and adhesive to cause same to contact and become adhesively bonded to said select tissue in the presence of body fluid,

(g) allowing said body fluid to degrade said microcapsules to permit the medical material contained thereby to be slowly released therefrom.