Fluid delivery micropump

• US 4,902,278 A
• Filed: 02/18/1987
• Issued: 02/20/1990
• Est. Priority Date: 02/18/1987
• Status: Expired due to Term

• Current Assignee: Cardinal Health 303 Incorporated (Cardinal Health, Inc.)
• Original Assignee: Ivax Corporation (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Maget, Henri J. R., Krejci, Paul K.
• Primary Examiner(s): Pellegrino, Stephen C.
• Application Number:
  US07/016,019
• Time in Patent Office: 1,098 Days
• Field of Search: 604/892, 604/891, 604/151, 604/132, 604/145, 604/141, 128/DIG. 12, 417/472-473, 429/27, 204/180, 204/299, 204/301
• US Class Current: 604/132
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: F04B 43/043 Micropumps
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

A prime mover module used in a fluid delivery micropump, especially for pharmaceutical purposes, transports an electrochemically active material, such as oxygen, at a steady rate across an ion exchange cell to apply external pressure to a collapsible reservoir and expel fluid therefrom. An air-actuated battery, such as a zinc-air battery, which is located in the module in a fixed closed circuit with the cell and which shares one of its electrodes with the cell, is activated by peeling off an adhesive tape covering air inlet ports to thereby establish a voltage gradient acrosss the cell and control the rate at which fluid is expelled from the reservoir in accordance with the value of a resistor in the cell/battery circuit. The reservoir is filled or refilled by inserting a vented needle into an air bleed port while discharging a fluid-filled syringe inserted into a fluid injection port. Cylindrical and flat configurations, suitable for external use, operate on atmospheric oxygen, while an implantable configuration operates on oxygen from a self-contained reservoir.

Claims

1. A prime move module, comprising:

a housing;

means for introducing an electrochemically active material into said housing from a first region;

an electrolytic membrane disposed in said housing and having first and second membrane surfaces;

a first material-pervious electrode disposed on said first membrane surface and a second material-pervious electrode disposed on said second membrane surface; and

an electrical power source disposed in said housing and having a pair of electrodes, one of said power source electrodes being integral with said first material-pervious electrode and having electrical communication means disposed within said housing for providing electrical communication between the other of said power source electrodes and said second material-pervious electrode, for establishing a voltage gradient across said electrolytic membrane to ionize said electrochemically active material at said first material-pervious electrode, transport said ions through said electrolytic membrane to said second material-pervious electrode, and reconvert said ions to molecules of said electrochemically active material which are evolved at said second material-pervious electrode into a second region, said power source including power source material that undergoes a chemical reaction which converts chemical energy into electrical energy when said power source material is exposed to said electrochemically active material.

2. Apparatus as set forth in claim 1, wherein said electrochemically active material comprises oxygen and said means for introducing said oxygen into said housing comprises at least one port formed in said housing to establish communication between the interior of said housing and an oxygen-containing environment in said first region.

3. Apparatus as set forth in claim 1, wherein said electrical communication means includes a registor.

4. Apparatus as set forth in claim 1, wherein said electrochemically active material comprises oxygen.

5. Apparatus as set forth in claim 1, wherein said electrical power source comprises a zinc-oxygen battery.

6. Apparatus as set forth in claim 1, wherein said other of the pair of electrodes is pervious to said electrochemically active material, thereby providing said means for introducing said electrochemically active material into said housing.

7. Fluid delivery apparatus, comprising:

a prime mover module having a housing;

means in said module for introducing electrochemically active material into said housing from a first region;

an electrolytic membrane in said module disposed in said housing and having first and second memberane surfaces;

a first material-pervious electrode disposed on said first membrane surface and a second material-pervious electrode disposed on said second membrane surface;

means disposed within said housing of said module connected to said first and second electrodes for establishing a voltage gradient across said electrolytic membrane to ionize said electrochemically active material at said first material-pervious electrode, transport said ions through said electrolytic membrane to said second material-pervious electrode, and reconvert said ions to molecules of said electrochemically active material which are evolved at said second material-pervious electrode into a second region, said means including power source material that undergoes a chemical reaction which converts chemical energy into electrical energy when said power source material is exposed to said electrochemically active material;

a fluid reservoir module having a housing adapted to receive said prime mover module;

a collapsible reservoir disposed in said reservoir housing, said reservoir containing a fluid to be pumped and having an exterior surface adapted to be in communication with said second region when said prime mover module is received in said reservoir module;

outlet means provided in said reservoir for permitting release of said fluid therefrom upon collapse of said reservoir, said reservoir being collapsed in response to pressure on said exterior surface caused by said evolution of material into said second region when said prime mover module is received in said reservoir module.

8. Apparatus as set forth in claim 7, wherein said first region comprises a reservoir in the prime mover module housing.

9. Apparatus as set forth in the claim 7, wherein said reservoir housing has a central portion and a peripheral portion having an internal annular cavity circumferentially disposed about said central portion, said prime mover module being disposed in said central portion and said collapsible reservoir being an annular reservoir disposed in said annular cavity, said reservoir housing further being provided with at least one passageway providing fluid communication between said central portion and annular cavity to enable said evolved electrochemically active material from said prime mover module to apply pressure to said exterior surface of said collapsible reservoir when said prime mover module is received in said reservoir module.

10. Apparatus as set forth in claim 9, wherein said prime mover module is selectively detachable from said peripheral portion of said housing.

11. A prime mover module, comprising:

a housing;

means for introducing electrochemically active material into said housing from a first region;

an electrolytic membrane disposed in said housing and having first and second membrane surfaces;

a first material-pervious electrode disposed on said first membrane surface and a second material-pervious electrode disposed on said second membrane surface;

an electrical power source in a fixed closed circuit with said first and second electrodes for establishing a voltage gradient across said electrolytic membrane which ionizes said electrochemically active material at said first material-pervious electrode, transports said ions through said electrolytic membrane to said second material-pervious electrode, and reconverts said ions to molecules of said electrochemically active material which are evolved at said second material-pervious electrode into a second region, said fixed closed circuit being wholly disposed within said housing;

said electrical power source comprising power source material that undergoes a chemical reaction which converts chemical energy into electrical energy when said power source material is exposed to a activating agent; and

wherein means are provided for selectively exposing said power source material to said activating agent.

12. Apparatus as set forth in claim 11, wherein said electrical power source further comprises a power source housing enclosing said power source material, and wherein said means for selectively exposing said power source material comprises at least one port formed in said power source housing to expose said power source material to an environment containing said activating agent and removable sealing means for closing said port.

13. Apparatus as set forth in claim 11, wherein said means for selectively exposing said power source material comprises regulator means for regulating said exposure of said power source material to said actuating agent.

14. Apparatus as set forth in claim 11, wherein said means for selectively exposing said power source material comprises at least one port formed in said power source housing, said port having a relatively small diameter which is selectively sized to regulate said exposure of said power source material to an environment containing said activating agent.

15. Apparatus as set forth in claim 11, wherein said means for selectively exposing said power source material comprises at least one port formed in said power source housing, said port being closed by a membrane which is impermeable to said activating agent, whereby said exposure of said power source material to said activating agent is regulated.

16. Fluid delivery apparatus, comprising:

a housing having a central portion and a peripheral portion with an internal annular cavity circumferentially disposed about said central portion;

means for introducing an electrochemically active material into said housing;

fluid pulp means disposed in said central portion for pressurizing a fluid, said fluid pump means including an electrolytic membrane disposed in said housing and having a first electrode and further including an electrical power source disposed in said housing and having a second electrode integral with said first electrode for establishing a voltage gradient across said electrolytic membrane, said electrical power source further comprising power source material that undergoes a chemical reaction which converts chemical energy into electrical energy when said power source material is exposed to said electrochemically active material;

an annular collapsible reservoir disposed in said cavity and containing a fluid to be pumped;

outlet means provided in said reservoir for permitting release of said fluid to be pumped upon collapse of said reservoir; and

at least one passageway in said housing providing fluid communication between said fluid pump means and said cavity to apply pressurized fluid from said fluid pump means to the external surface of said collapsible reservoir, said reservoir being collapsed in response to said application of pressurized fluid.

17. Apparatus as set forth in claim 16, wherein said central portion of said housing is selectively detachable from said peripheral portion of said housing.

18. Apparatus as set forth in claim 16, wherein said housing is provided with a pair of closable port means, one of said port means being in communication with the interior of said collapsible reservoir to permit introduction of fluid therein and the other of said port means being communication with said cavity to permit venting of said cavity during said introduction of fluid into said reservoir.

19. A prime mover module, comprising:

a housing;

means for introducing an electrochemically active material into said housing;

an electrolytic membrane disposed in said housing, said membrane having a first and second membrane surfaces, a first membrane electrode disposed on said first membrane surface, and a second membrane electrode disposed on said second membrane surface;

an electrical power source disposed in said housing and including first and second power source electrodes, said second power source electrode being integral with said first membrane electrode, and including circuit means disposed within said housing for electrically communicating between said first power source electrode and said second membrane electrode, said power source including power source material that undergoes a chemical reaction which converts chemical energy into electrical energy when said power source material is exposed to said electrochemically active material.

20. The prime mover module of claim 19, wherein said first and second membrane electrodes are material-pervious electrodes.

21. The prime mover module of claim 19, wherein said circuit means includes a resistor.