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Novel amphiphilic nucleic acid conjugates

  • US 4,904,582 A
  • Filed: 06/11/1987
  • Issued: 02/27/1990
  • Est. Priority Date: 06/11/1987
  • Status: Expired due to Fees
First Claim
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1. A method for inhibiting the maturation or translation of a messenger RNA in a cell, said method comprising:

  • contacting said cell with a composition comprising an oligonucleotide sequence complementary to a transcription product of said cell and a group covalently linked to said oligonucleotide sequence to provide an amphiphilic molecule, whereby said composition migrates into the cell interior resulting in the inhibition of maturation and/or translation of said transcription product.

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