Therapeutic somatostatin analogs
First Claim
1. An octapeptide of the formula:
- ##STR3## wherein X is H, OH, CH3, or a halogen, or a pharmaceutically acceptable salt thereof.
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Abstract
An octapeptide of the formula: ##STR1## wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1 CO (where R1 is C1-20 alkyl, C3-20 alkenyl, C3-20 alkinyl, phenyl, naphthyl, or C7-10 phenylalkyl), or R2 OCO (where R2 is C1-10 alkyl or C7-10 phenylalkyl), provided that when one of A1 or A2 is R1 CO or R2 OCO, the other must be H; A3 is CH2 -A6 (where A6 is pentafluorophenyl, naphthyl, pyridyl, or phenyl); A4 is o- m- or p-substituted X-Phe (where X is a halogen, H, NO2, OH, NH2, or C1-3 alkyl), pentafluoro-Phe, or β-Nal; A5 is Thr, Ser, Phe, Val, α-aminobutyric acid, or Ile, provided that when A3 is phenyl, A1 is H, and A2 is H, A5 cannot be Val; and A7 is Thr, Trp, or β-Nal; or a pharmaceutically acceptable salt thereof.
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11 Claims
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1. An octapeptide of the formula:
- ##STR3## wherein X is H, OH, CH3, or a halogen, or a pharmaceutically acceptable salt thereof.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
Specification