Impedance cardiometer

• US 4,905,705 A
• Filed: 03/03/1989
• Issued: 03/06/1990
• Est. Priority Date: 03/03/1989
• Status: Expired due to Fees

• Current Assignee: Research Triangle Institute
• Original Assignee: Research Triangle Institute
• Inventors: Teague, Steve M., Kizakevich, Paul N.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): GETZOW, SCOTT M
• Application Number:
  US07/318,277
• Time in Patent Office: 368 Days
• Field of Search: 128/696, 128/734, 128/723, 128/700
• US Class Current: 600/509
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A heart monitoring system for assessing a patient'"'"'s cardiac condition. Bioimpedance components induce an electric current through the thorax of a patient'"'"'s body and a first signal representing amplitude of transthoracic impedance as a function of time is obtained. Electrocardiograph components obtain an electrocardiograph signal from the patient simultaneously with the first signal. First processing circuitry is connected to the bioimpedance components for processing the first signal and producing therefrom a second signal representing cardiovascular hemodynamic changes as a function of time. Second processing circuitry is connected to the electrocardiograph components for measuring changes in the electrocardiograph signal. An analyzer is connected to the first and second processing circuits for producing an output indicating changes in a portion of the second signal over a period of time relative to changes in the electrocardiograph signal over the same period of time. A presentation device presents a visualization of the output of the analyzer for use in providing an assessment of cardiac condition.

Claims

1. A heart monitoring system for assessing a patient'"'"'s cardiac condition comprising:

bioimpedance means for inducing an electric current through the thorax of a patient'"'"'s body and obtaining a first signal representing amplitude of transthoracic impedance as a function of time;

electrocardiograph means for obtaining an electrocardiograph signal from the patient simultaneously with obtaining the first signal;

first processing means connected to said bioimpedance means for processing the first signal and producing therefrom a second signal representing cardiovascular hemodynamic changes as a function of time;

second processing means connected to said electrocardiograph means for measuring changes in the electrocardiograph signal;

analysis means connected to said first and second processing means for producing an output indicating changes in a portion of the second signal over a period of time relative to changes in the electrocardiograph signal over the same period of time; and

presentation means connected to said analysis means for visually presenting the output of said analysis means for use in providing an assessment of cardiac condition.

2. The system of claim 1, wherein said second processing means includes an ST-segment measuring means for measuring changes in the ST-segment of the electrocardiograph signal.

3. The system of claim 2, wherein said first processing means includes means for producing an acceleration signal indicating aortic blood acceleration and said analysis means includes means for indicating changes in the acceleration signal over a period of time relative to changes in the ST-segment of the electrocardiograph signal over the same period of time.

4. The system of claim 3, wherein said analysis means includes combining means for combining changes in the acceleration signal with changes in the ST-segment of the electrocardiograph signal over the same period of time to produce a parameter having cardiac diagnostic sensitivity.

5. The system of claim 4, wherein said combining means forms a ratio between a change in amplitude of the acceleration signal and a change in the ST-segment of the electrocardiograph signal over the same period of time.

6. The system of claim 5, wherein the change in ST-segment portion of the electrocardiograph signal comprises a change in ST-segment amplitude.

7. The system of claim 1, wherein said second processing means includes a heartrate measuring means for measuring changes in heart rate as a function of time.

8. The system of claim 7, wherein said first processing means includes means for producing an acceleration signal indicating aortic blood acceleration and said analysis means includes means for indicating changes in the acceleration signal over a period of time relative to changes in heartrate over the same period of time.

9. The system of claim 8, wherein said analysis means includes combining means for combining changes in amplitude of the acceleration signal with changes in heartrate over the same period of time to produce a parameter having cardiac diagnostic sensitivity.

10. The system of claim 9, wherein said combining means forms a ratio between a change in the acceleration signal amplitude and a change in heartrate.

11. A method for diagnosing coronary artery disease in a patient comprising:

measuring transthoracic impedance amplitude as a function of time while a patient is at rest and during exercise;

obtaining an electrocardiograph of the patient simultaneously with said measuring step;

processing the transthoracic impedance amplitude as a function of time to obtain a signal representing changes in cardiovascular hemodynamics as a function of time;

deriving a value for a predetermined parameter obtained from a selected portion of the signal during a cardiac cycle at rest and from a corresponding selected portion of the signal during a cardiac cycle while exercising;

forming the difference between the parameter values at rest and during exercise;

determining a change in a predetermined aspect of the electrocardiograph between respective ones of the cardiac cycles at rest and during exercise used in said deriving step; and

combining the difference in parameter values and the change in the predetermined aspect of the electrocardiograph to form a hybrid indicator for providing an assessment of cardiac condition.

12. The method of claim 11, wherein said determining step includes determining a change in the ST-segment of the electrocardiograph between the respective ones of the cardiac cycles at rest and during exercise.

13. The method of claim 12 wherein said deriving step includes deriving values for aortic blood acceleration at rest and during exercise, and said forming and combining steps include using values of aortic acceleration as the parameter values.

14. The method of claim 13, wherein said determining step includes determining a change in ST-segment amplitude.

15. The method of claim 14, wherein said combining step includes forming a ratio between (a) the difference in values for blood acceleration at rest and during exercise, and (b) the change in ST-segment amplitude between rest and exercise.

16. The method of claim 11, wherein said determining step includes determining a change in heartrate between the respective ones of the cardiac cycles at rest and during exercise.

17. The method of claim 16, wherein said deriving step includes deriving values for aortic blood acceleration at rest and during exercise, and said forming and combining steps include using values of aortic acceleration as the parameter values.

18. The method of claim 17, wherein said combining step includes forming a ratio between (a) the difference in values for aortic blood acceleration at rest and during exercise, and (b) the change in heartrate between rest and exercise.